T cell-derived lymphotoxin regulates liver regeneration.
T cell-derived lymphotoxin regulates liver regeneration.
复制标题
T细胞衍生的淋巴毒素调节肝脏再生。
DOI：
10.1053/j.gastro.2008.09.015
复制
发表时间：
2009-02
期刊：
影响因子：
29.4
通讯作者：
Anders RA
中科院分区：
文献类型：
--
作者：
Tumanov AV;Koroleva EP;Christiansen PA;Khan MA;Ruddy MJ;Burnette B;Papa S;Franzoso G;Nedospasov SA;Fu YX;Anders RA
The ability of the liver to regenerate hepatic mass is essential to withstanding liver injury. The process of liver regeneration is tightly regulated by distinct signaling cascades involving components of the innate immune system, cytokines, and growth factors. However, the role of the adaptive immune system in regulation of liver regeneration is not well-defined. The role of adaptive immune system in liver regeneration was investigated in lymphocyte-deficient mice and in conditional lymphotoxin-deficient mice. A model of liver regeneration after 70% partial hepatectomy was used, followed by examination of liver pathology, survival, DNA synthesis, and cytokine expression. We found that mice deficient in T cells show a reduced capacity for liver regeneration following partial hepatectomy. Furthermore, surface lymphotoxin, provided by T cells, is critical for liver regeneration. Mice specifically deficient in T-cell lymphotoxin had increased liver damage and a reduced capacity to initiate DNA synthesis after partial hepatectomy. Transfer of splenocytes from wild-type but not lymphotoxin-deficient mice improved liver regeneration in T cell-deficient mice. We found that an agonistic antibody against the lymphotoxin β receptor was able to facilitate liver regeneration by reducing liver injury, increasing interleukin-6 production, hepatocyte DNA synthesis, and survival of lymphocyte-deficient (Rag) mice after partial hepatectomy. The adaptive immune system directly regulates liver regeneration via a T cell-derived lymphotoxin axis, and pharmacological stimulation of lymphotoxin β receptor might represent a novel therapeutic approach to improve liver regeneration.
登录
查看更多内容
影响因子：
56.9
作者：
Lo, James C.;Wang, Yugang;Fu, Yang-Xin
通讯作者：
Fu, Yang-Xin
影响因子：
13.5
作者：
Fausto, N;Campbell, JS;Riehle, KJ
通讯作者：
Riehle, KJ
影响因子：
--
作者：
AKERMAN, P;COTE, P;DIEHL, AM
通讯作者：
DIEHL, AM
HBV 转基因小鼠肝脏再生受损与激活的肝脏 NKT 细胞相关
影响因子：
13.5
作者：
Dong, Zhongjun;Zhang, Jianhong;Tian, Zhigang
通讯作者：
Tian, Zhigang
影响因子：
1.9
作者：
Greene, AK;Puder, M
通讯作者：
Puder, M