iPSC-Derived Natural Killer Cell Therapies - Expansion and Targeting.
iPSC-Derived Natural Killer Cell Therapies - Expansion and Targeting.
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DOI：
10.3389/fimmu.2022.841107
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发表时间：
2022
影响因子：
7.3
通讯作者：
Kaufman DS
中科院分区：
文献类型：
--
作者：
Goldenson BH;Hor P;Kaufman DS
用同种异体自然杀伤（NK）细胞疗法治疗癌症已经看到了快速发展，特别是针对血液恶性肿瘤的使用。基于NK细胞的过继转移治疗复发性或难治性恶性肿瘤的临床试验使用了外周血、脐带血和多能干细胞衍生的NK细胞，每种方法都在持续进行临床开发。提高这些疗法的效力依赖于基因修饰以改善肿瘤靶向并增强NK细胞的扩增和持久性。诱导多能干细胞（iPSC）衍生的NK细胞允许常规靶向引入遗传修饰和扩增衍生自克隆起始细胞群体的所得NK细胞。在这篇综述中，我们讨论并总结了最近在开发新的iPSC衍生NK细胞疗法方面的重要进展，重点是改善癌症的靶向。然后，我们讨论了扩增iPSC衍生的NK细胞的方法的改进以及如何增强iPSC-NK细胞的持久性。最后，我们描述了这些进展可能如何在未来的NK细胞为基础的治疗产品，用于血液系统恶性肿瘤和实体瘤的治疗联合收割机。
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid development, especially use against hematologic malignancies. Clinical trials of NK cell-based adoptive transfer to treat relapsed or refractory malignancies have used peripheral blood, umbilical cord blood and pluripotent stem cell-derived NK cells, with each approach undergoing continued clinical development. Improving the potency of these therapies relies on genetic modifications to improve tumor targeting and to enhance expansion and persistence of the NK cells. Induced pluripotent stem cell (iPSC)-derived NK cells allow for routine targeted introduction of genetic modifications and expansion of the resulting NK cells derived from a clonal starting cell population. In this review, we discuss and summarize recent important advances in the development of new iPSC-derived NK cell therapies, with a focus on improved targeting of cancer. We then discuss improvements in methods to expand iPSC-derived NK cells and how persistence of iPSC-NK cells can be enhanced. Finally, we describe how these advances may combine in future NK cell-based therapy products for the treatment of both hematologic malignancies and solid tumors.
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影响因子：
11.2
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.0611662104
发表时间：
2007-05-29
影响因子：
11.1
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影响因子：
39.3
作者：
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