Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy.
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy.
复制标题
DOI：
10.1038/s41392-020-00348-8
复制
发表时间：
2020-10-29
影响因子：
39.3
通讯作者：
Xu F
中科院分区：
文献类型：
--
作者：
Cao Y;Wang X;Jin T;Tian Y;Dai C;Widarma C;Song R;Xu F
最近的研究表明，自然杀伤（NK）细胞在免疫治疗中具有治疗多种类型癌症的潜力。NK细胞是先天淋巴样细胞，在肿瘤监测和控制中发挥重要作用，有效地杀死肿瘤，不需要主要的组织相容性复合体。NK作为癌症治疗靶点的潜力的发现让肿瘤学家们松了口气，因为他们面临着越来越多的化疗耐药癌症的挑战。NK细胞对实体肿瘤和血液学肿瘤显示出巨大的潜力，并逐渐显示出作为癌症免疫治疗靶点的希望。这些细胞的效应作用依赖于抑制和激活信号的平衡。当NK细胞的抑制受体过度表达时，了解各种免疫检查点分子在NK细胞衰竭和损伤中的作用在癌症免疫治疗研究和临床实施中尤为重要。新出现的免疫检查点受体和分子在肿瘤微环境中介导NK细胞功能障碍；这就需要进一步探索额外的NK细胞相关免疫检查点，这些检查点可能被用来增强对难治性癌症的免疫反应。因此，本文将重点介绍免疫检查点分子和受体在NK细胞功能调节中的作用及其在肿瘤免疫治疗中的潜在应用。
Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles in tumor surveillance and control that efficiently kill the tumor and do not require the major histocompatibility complex. The discovery of the NK’s potential as a promising therapeutic target for cancer is a relief to oncologists as they face the challenge of increased chemo-resistant cancers. NK cells show great potential against solid and hematologic tumors and have progressively shown promise as a therapeutic target for cancer immunotherapy. The effector role of these cells is reliant on the balance of inhibitory and activating signals. Understanding the role of various immune checkpoint molecules in the exhaustion and impairment of NK cells when their inhibitory receptors are excessively expressed is particularly important in cancer immunotherapy studies and clinical implementation. Emerging immune checkpoint receptors and molecules have been found to mediate NK cell dysfunction in the tumor microenvironment; this has brought up the need to explore further additional NK cell-related immune checkpoints that may be exploited to enhance the immune response to refractory cancers. Accordingly, this review will focus on the recent findings concerning the roles of immune checkpoint molecules and receptors in the regulation of NK cell function, as well as their potential application in tumor immunotherapy.
登录
查看更多内容
影响因子：
5.7
作者：
Adachi K;Tamada K
通讯作者：
Tamada K
影响因子：
--
作者：
Bauman Y;Drayman N;Ben-Nun-Shaul O;Vitenstein A;Yamin R;Ophir Y;Oppenheim A;Mandelboim O
通讯作者：
Mandelboim O
影响因子：
16.6
作者：
Burton, Bronwen R.;Britton, Graham J.;Fang, Hai;Verhagen, Johan;Smithers, Ben;Sabatos-Peyton, Catherine A.;Carney, Laura J.;Gough, Julian;Strobel, Stephan;Wraith, David C.
通讯作者：
Wraith, David C.
影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
Spies, T
影响因子：
--
作者：
Beldi-Ferchiou A;Lambert M;Dogniaux S;Vély F;Vivier E;Olive D;Dupuy S;Levasseur F;Zucman D;Lebbé C;Sène D;Hivroz C;Caillat-Zucman S
通讯作者：
Caillat-Zucman S