C-Elastography: In Vitro Feasibility Phantom Study.

C-Elastography: In Vitro Feasibility Phantom Study.
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DOI:
10.1016/j.ultrasmedbio.2020.02.005
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发表时间:
2020-07
影响因子:
2.9
通讯作者:
Fatemi M
Fatemi M
中科院分区:
医学3区
文献类型:
--
作者:
Shahraki DP;Kumar V;Ghavami S;Urban MW;Alizad A;Guzina BB;Fatemi M

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C 弹性成像 (CE) 是一种新型超声技术,利用声辐射力 (ARF) 产生的低频 (150 – 250 Hz) 剪切波来局部绘制软组织的非线性弹性图。 CE 基于最近的一项发现,即各向同性组织状固体中 ARF 的大小与三阶弹性模量 C 线性相关,C 负责偏向和体积本构行为之间的耦合。这项工作的主要目的是通过对明胶块中的离体组织和模拟组织内含物进行初步研究,检验 C 弹性成像在区分和表征软组织方面的可行性和性能。在这种情况下,CE 技术结合使用超声运动传感和三维粘弹动力学模拟来估计非线性模量 C。由于超声聚焦本质上将 ARF 限制在一个小区域内,因此 CE 提供了在 O(mm3) 体积内测量 C 的方法。配备此类数据分析后,我们对嵌入明胶基质中的基于琼脂的异种移植和正常乳腺组织样本进行了体外 CE 实验。复合 C 弹性图表明,在特征软质和硬质夹杂物内部的推动点处,具有明显(且尖锐)的 C 对比度,平均值分别为 1.9 和 5.6。
C-elastography (CE) is a new ultrasound technique to locally map the nonlinear elasticity of soft tissue using low-frequency (150 – 250 Hz) shear waves generated by the acoustic radiation force (ARF). The CE is based on a recent finding that the magnitude of the ARF in an isotropic tissue-like solid is related linearly to a third-order modulus of elasticity, C, that is responsible for the coupling between deviatoric and volumetric constitutive behaviors. The main objective of this work is to examine the feasibility and performance of C-elastography in differentiating and characterizing soft tissue via a pilot study on ex vivo tissue and tissue-mimicking inclusions cast in a gelatin block. In this vein, the CE technique deploys a combination of ultrasound motion sensing and three-dimensional visco-elastodynamic simulation to estimate the nonlinear modulus C. Since ultrasound focusing inherently confines the ARF to a small region, CE provides the means for measuring C within O(mm3) volumes. Equipped with such data analysis, we performed in vitro CE experiments on agar-based, xenograft, and normal breast tissue samples embedded in a gelatin matrix. The compound C-elastograms indicate marked (and sharp) C-contrast, with the average values of 1.9 and 5.6, at push points inside the featured soft and hard inclusions, respectively.
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