Zinc chromate induces chromosome instability and DNA double strand breaks in human lung cells.
Zinc chromate induces chromosome instability and DNA double strand breaks in human lung cells.
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DOI：
10.1016/j.taap.2008.10.010
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发表时间：
2009-02-01
影响因子：
3.8
通讯作者：
Wise JP Sr
中科院分区：
文献类型：
--
作者：
Xie H;Holmes AL;Young JL;Qin Q;Joyce K;Pelsue SC;Peng C;Wise SS;Jeevarajan AS;Wallace WT;Hammond D;Wise JP Sr
六价铬Cr（VI）是一种呼吸道毒物和致癌物，溶解度在其致癌潜力中起着重要作用。铬酸锌是一种不溶于水的铬（VI）化合物，在流行病学研究中已被证明是致癌的，并在实验动物中诱发肿瘤，但其遗传毒性知之甚少。我们的研究表明，铬酸锌诱导的细胞毒性，染色体损伤和DNA双链断裂在人肺细胞的浓度依赖性增加。在响应于锌铬诱导的断裂，MRE 11表达增加，ATM和ATR被磷酸化，表明DNA双链断裂修复系统在细胞中启动。此外，我们的数据表明，锌铬诱导的双链断裂只观察到在G2/M期人口，没有观察到显着量的双链断裂在G1和S期细胞。这些数据将有助于了解铬酸锌的毒性和致癌机制。
Hexavalent chromium Cr(VI) is a respiratory toxicant and carcinogen, with solubility playing an important role in its carcinogenic potential. Zinc chromate, a water insoluble or ‘particulate’ Cr(VI) compound, has been shown to be carcinogenic in epidemiology studies and to induce tumors in experimental animals, but its genotoxicity is poorly understood. Our study shows that zinc chromate induced concentration-dependent increases in cytotoxicity, chromosome damage and DNA double strand breaks in human lung cells. In response to zinc chromate-induced breaks, MRE11 expression was increased and ATM and ATR were phosphorylated, indicating that the DNA double strand break repair system was initiated in the cells. In addition, our data show that zinc chromate-induced double strand breaks were only observed in the G2/M phase population, with no significant amount of double strand breaks observed in G1 and S phase cells. These data will aid in understanding the mechanisms of zinc chromate toxicity and carcinogenesis.
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影响因子：
4.8
作者：
Ha, N;Ceryak, S;Patierno, SR
通讯作者：
Patierno, SR
DOI：
10.1097/00043764-198001000-00008
发表时间：
1980-01-01
影响因子：
3.2
作者：
DALAGER, NA;MASON, TJ;PAYNE, WW
通讯作者：
PAYNE, WW
影响因子：
56.9
作者：
Lee, JH;Paull, TT
通讯作者：
Paull, TT
影响因子：
1.7
作者：
Iliakis, G;Wang, H;Pantelias, G
通讯作者：
Pantelias, G
影响因子：
7.7
作者：
KANO, K;HORIKAWA, M;YAMAGUCHI, S
通讯作者：
YAMAGUCHI, S