DNA signals at isoform promoters.
DNA signals at isoform promoters.
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同工型启动子处的 DNA 信号
DOI：
10.1038/srep28977
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发表时间：
2016-06-29
影响因子：
4.6
通讯作者：
Dai X
中科院分区：
文献类型：
--
作者：
Dai Z;Xiong Y;Dai X
转录异质性在基因组中是广泛的，并且大多数基因表达可变的转录异构体。然而，一个基因的可变转录异构体是否由共同的启动子元件调控仍有待阐明。在这里，我们调查是否同种型启动子的一个基因有单独的DNA信号的转录和翻译起始。我们发现，TATA盒和核小体不利的DNA序列是普遍存在于不同的转录异构体启动子的一个基因。这些DNA信号在物种之间是保守的。转录物同种型在其起始位点周围具有RNA决定的非结构化区域。我们发现这些DNA/RNA特征促进同种型转录和翻译。这些结果表明，DNA编码的转录异构体的产生机制。
Transcriptional heterogeneity is extensive in the genome and most genes express variable transcript isoforms. However, whether variable transcript isoforms of one gene are regulated by common promoter elements remain to be elucidated. Here, we investigated whether isoform promoters of one gene have separated DNA signals for transcription and translation initiation. We found that TATA box and nucleosome-disfavored DNA sequences are prevalent in distinct transcript isoform promoters of one gene. These DNA signals are conserved among species. Transcript isoform has a RNA-determined unstructured region around its start site. We found that these DNA/RNA features facilitate isoform transcription and translation. These results suggest a DNA-encoded mechanism by which transcript isoform is generated.
影响因子：
14.9
作者：
Luykx P;Bajić IV;Khuri S
通讯作者：
Khuri S