Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging.
Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging.
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DOI：
10.1002/jso.23740
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发表时间：
2014-12
影响因子：
2.5
通讯作者：
Vahrmeijer, A. L.
中科院分区：
文献类型：
--
作者：
Schaafsma, B. E.;Verbeek, F. P. R.;Elzevier, H. W.;Tummers, Q. R. J. G.;Van der Vorst, J. R.;Frangioni, J. V.;Van de Velde, C. J. H.;Pelger, R. C. M.;Vahrmeijer, A. L.
Unlike other cancers, the Sentinel Lymph Node (SLN) procedure in bladder cancer requires special attention to the injection technique. The aim of this study was to assess feasibility and to optimize tracer injection technique for SLN mapping in bladder cancer patients using NIR fluorescence imaging. Twenty patients with invasive bladder cancer scheduled for radical cystectomy were prospectively enrolled. Indocyanine green (ICG) bound to human serum albumin (complex ICG:HSA; 500 μM) was injected peritumourally to permit SLN mapping. ICG:HSA was first administrated serosally (n=5), and subsequently mucosally by cystoscopic injection (n=15). In the last cohort of 12 patients treated with cystoscopic injection, the bladder was kept filled with saline for at least 15 minutes. Fluorescent lymph nodes were observed only in the patient group with cystoscopic injection of ICG:HSA. Filling of the bladder post-injection was of added value to promote drainage of ICG:HSA to the lymph nodes, and in 11 of these 12 patients (92%) one or more NIR fluorescent lymph nodes were identified. The current study demonstrates proof-of-principle of using NIR fluorescence imaging for SLN identification in bladder cancer. Cystoscopic injection with distension of the bladder appears optimal for SLN mapping.
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影响因子：
2.2
作者：
Schaafsma, Boudewijn E.;Verbeek, Floris P. R.;van der Vorst, Joost R.;Hutteman, Merlijn;Kuppen, Peter J. K.;Frangioni, John V.;van de Velde, Cornelis J. H.;Vahrmeijer, Alexander L.
通讯作者：
Vahrmeijer, Alexander L.
影响因子：
2.5
作者：
Schaafsma, Boudewijn E.;Mieog, J. Sven D.;Hutteman, Merlijn;Van der Vorst, Joost R.;Kuppen, Peter J. K.;Lowik, Clemens W. G. M.;Frangioni, John V.;Van de Velde, Cornelis J. H.;Vahrmeijer, Alexander L.
通讯作者：
Vahrmeijer, Alexander L.
影响因子：
45.3
作者：
Leijte, Joost A. P.;Hughes, Ben;Horenblas, Simon
通讯作者：
Horenblas, Simon
影响因子：
6.6
作者：
Sherif, A;De la Torre, M;Thörn, M
通讯作者：
Thörn, M
影响因子：
9
作者：
Cox, CE;Pendas, S;Reintgen, DS
通讯作者：
Reintgen, DS