Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche.
Visceral mesoderm signaling regulates assembly position and function of the Drosophila testis niche.
复制标题
DOI：
10.1016/j.devcel.2022.03.009
复制
发表时间：
2022-04-25
影响因子：
11.8
通讯作者：
DiNardo, Stephen
中科院分区：
文献类型：
--
作者：
Anllo, Lauren;DiNardo, Stephen
组织稳态通常需要适当放置的生态位来支持干细胞。定位利基的形态发生过程刚刚被描述。对于果蝇睾丸，我们最近表明，在性腺发生早期位于不同位置的前生态位细胞必须在性腺前部聚集成一个集体。我们现在发现相邻内脏中胚层发出的 Slit 和 FGF 信号调节组装。为了响应信号传导，生态位细胞表达胰岛，我们发现这也是生态位组装所必需的。如果没有信号传导，距前部最远的生态位细胞将无法迁移，保持分散状态。这些生态位的功能被严重破坏，生态位细胞逃避细胞周期静止，其向初期干细胞库发出信号的能力受到损害，并且无法正确定向干细胞分裂。我们的工作确定了睾丸生态位正确组装和放置所需的外在信号传导和内在反应。 Anllo 和 DiNardo 研究了组织发育过程中干细胞生态位（干细胞微环境）的形成。他们阐明了组装生态位所需的信号，表明适当的组装是生态位功能所必需的，并揭示了一个组织如何影响相邻组织中生态位的发育。
Tissue homeostasis often requires a properly placed niche to support stem cells. Morphogenetic processes that position a niche are just being described. For the Drosophila testis, we recently showed that pro-niche cells, specified at disparate positions during early gonadogenesis, must assemble into one collective at the anterior of the gonad. We now find that Slit and FGF signals emanating from adjacent visceral mesoderm regulate assembly. In response to signaling, niche cells express islet, which we find is also required for niche assembly. Without signaling, niche cells specified furthest from the anterior are unable to migrate, remaining dispersed. The function of such niches is severely disrupted, with niche cells evading cell cycle quiescence, compromised in their ability to signal the incipient stem cell pool, and failing to orient stem cell divisions properly. Our work identifies both extrinsic signaling and intrinsic responses required for proper assembly and placement of the testis niche. Anllo and DiNardo investigate the formation of a stem cell niche, the stem cell microenvironment, during tissue development. They elucidate signaling required to assemble a niche, show that proper assembly is required for niche function, and reveal how one tissue can influence the development of a niche in an adjacent tissue.
登录
查看更多内容
影响因子：
7.7
作者：
Chen C;Cummings R;Mordovanakis A;Hunt AJ;Mayer M;Sept D;Yamashita YM
通讯作者：
Yamashita YM
影响因子：
16.2
作者：
Isaacman-Beck J;Schneider V;Franzini-Armstrong C;Granato M
通讯作者：
Granato M
影响因子：
2.7
作者：
CIMBORA, DM;SAKONJU, S
通讯作者：
SAKONJU, S
影响因子：
8.8
作者：
Greenspan LJ;Matunis EL
通讯作者：
Matunis EL
影响因子：
11.8
作者：
Herrera SC;Sainz de la Maza D;Grmai L;Margolis S;Plessel R;Burel M;O'Connor M;Amoyel M;Bach EA
通讯作者：
Bach EA