The novel Mechanical Ventilator Milano for the COVID-19 pandemic.
The novel Mechanical Ventilator Milano for the COVID-19 pandemic.
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新型机械呼吸机Milano用于COVID-19大流行。
DOI：
10.1063/5.0044445
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Zambrano V
中科院分区：
文献类型：
--
作者：
Abba A;Accorsi C;Agnes P;Alessi E;Amaudruz P;Annovi A;Desages FA;Back S;Badia C;Bagger J;Basile V;Batignani G;Bayo A;Bell B;Beschi M;Biagini D;Bianchi G;Bicelli S;Bishop D;Boccali T;Bombarda A;Bonfanti S;Bonivento WM;Bouchard M;Breviario M;Brice S;Brown R;Calvo-Mozota JM;Camozzi L;Camozzi M;Capra A;Caravati M;Carlini M;Ceccanti A;Celano B;Cela Ruiz JM;Charette C;Cogliati G;Constable M;Crippa C;Croci G;Cudmore S;Dahl CE;Dal Molin A;Daley M;Di Guardo C;D'Avenio G;Davignon O;Del Tutto M;De Ruiter J;Devoto A;Diaz Gomez Maqueo P;Di Francesco F;Dossi M;Druszkiewicz E;Duma C;Elliott E;Farina D;Fernandes C;Ferroni F;Finocchiaro G;Fiorillo G;Ford R;Foti G;Fournier RD;Franco D;Fricbergs C;Gabriele F;Galbiati C;Garcia Abia P;Gargantini A;Giacomelli L;Giacomini F;Giacomini F;Giarratana LS;Gillespie S;Giorgi D;Girma T;Gobui R;Goeldi D;Golf F;Gorel P;Gorini G;Gramellini E;Grosso G;Guescini F;Guetre E;Hackman G;Hadden T;Hawkins W;Hayashi K;Heavey A;Hersak G;Hessey N;Hockin G;Hudson K;Ianni A;Ienzi C;Ippolito V;James CC;Jillings C;Kendziora C;Khan S;Kim E;King M;King S;Kittmer A;Kochanek I;Kowalkowski J;Krücken R;Kushoro M;Kuula S;Laclaustra M;Leblond G;Lee L;Lennarz A;Leyton M;Li X;Liimatainen P;Lim C;Lindner T;Lomonaco T;Lu P;Lubna R;Lukhanin GA;Luzón G;MacDonald M;Magni G;Maharaj R;Manni S;Mapelli C;Margetak P;Martin L;Martin S;Martínez M;Massacret N;McClurg P;McDonald AB;Meazzi E;Migalla R;Mohayai T;Tosatti LM;Monzani G;Moretti C;Morrison B;Mountaniol M;Muraro A;Napoli P;Nati F;Natzke CR;Noble AJ;Norrick A;Olchanski K;Ortiz de Solorzano A;Padula F;Pallavicini M;Palumbo I;Panontin E;Papini N;Parmeggiano L;Parmeggiano S;Patel K;Patel A;Paterno M;Pellegrino C;Pelliccione P;Pesudo V;Pocar A;Pope A;Pordes S;Prelz F;Putignano O;Raaf JL;Ratti C;Razeti M;Razeto A;Reed D;Refsgaard J;Reilly T;Renshaw A;Retriere F;Riccobene E;Rigamonti D;Rizzi A;Rode J;Romualdez J;Russel L;Sablone D;Sala S;Salomoni D;Salvo P;Sandoval A;Sansoucy E;Santorelli R;Savarese C;Scapparone E;Schaubel T;Scorza S;Settimo M;Shaw B;Shawyer S;Sher A;Shi A;Skensved P;Slutsky A;Smith B;Smith NJT;Stenzler A;Straubel C;Stringari P;Suchenek M;Sur B;Tacchino S;Takeuchi L;Tardocchi M;Tartaglia R;Thomas E;Trask D;Tseng J;Tseng L;VanPagee L;Vedia V;Velghe B;Viel S;Visioli A;Viviani L;Vonica D;Wada M;Walter D;Wang H;Wang MHLS;Westerdale S;Wood D;Yates D;Yue S;Zambrano V
本文介绍了米兰机械呼吸机（MVM），这是一种新型强化治疗机械呼吸机，专为应对COVID-19大流行而设计的快速、大规模、低成本生产。MVM不需要移动机械部件，只需要一个压缩氧气和医用空气源即可操作，旨在支持COVID-19患者通常需要的长期有创通气，并在压力调节通气模式下运行，从而最大限度地降低进一步肺部创伤的风险。在实验室使用呼吸模拟器对MVM进行了ISO标准的广泛测试，在输入和测量的呼吸参数之间具有良好的一致性，并且在故障条件和稳定性测试中表现正确。MVM已获得美国食品和药物管理局（FDA）的紧急使用授权，可在COVID-19大流行期间用于医疗保健机构，并根据与COVID-19相关的使用临时命令获得加拿大卫生部医疗器械进口或销售授权。在获得这些认证后，正在进行大规模生产，并正在几个国家进行分销。MVM是由呼吸保健专业人员和实验物理学家与工业合作伙伴合作，在几个月内设计、测试、准备认证和批量生产的，是世界上任何地方应对此次大流行的优秀候选呼吸机。
This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world.
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DOI：
10.1063/5.0012796
发表时间：
2020-07-01
期刊：
Physics of fluids (Woodbury, N.Y. : 1994)
影响因子：
--
作者：
Munir B;Xu Y
通讯作者：
Xu Y
影响因子：
10.7
作者：
MANLEY, RW
通讯作者：
MANLEY, RW
影响因子：
9.6
作者：
Marik, PE;Krikorian, J
通讯作者：
Krikorian, J
影响因子：
1.1
作者：
Walter JM;Corbridge TC;Singer BD
通讯作者：
Singer BD
影响因子：
15.1
作者：
Morita, Plinio P.;Weinstein, Peter B.;Cafazzo, Joseph A.
通讯作者：
Cafazzo, Joseph A.