RNA polymerase II transcription elongation control.
RNA polymerase II transcription elongation control.
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DOI：
10.1021/cr400105n
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发表时间：
2013-11-13
期刊：
影响因子：
62.1
通讯作者：
Price, David H.
中科院分区：
文献类型：
--
作者：
Guo, Jiannan;Price, David H.
基因表达的调控是决定细胞身份、发育和对细胞环境反应的关键。DNA是遗传信息的遗传来源，基因表达的调控始于选择哪些基因将进行转录。然后利用转录产物RNA产生功能性产物，包括翻译成蛋白质或加工成功能性RNA。在真核生物中，蛋白质编码基因通过RNA聚合酶II （Pol II）转录成信使RNA （mRNA）。这些短寿命RNA物种具有多种特征，从产生到降解受到广泛调控。在微阵列和高通量测序等方法的帮助下，Pol II转录研究的规模和深度都得到了爆炸式的发展。来自许多来源的数据的绝对数量和复杂性甚至引发了对用于分析和解释的方法进行仔细重新思考的呼吁。然而，毫无疑问，转录调控严重影响基因表达，从而影响细胞状态和细胞特性。Pol II的转录始于预起始复合物（PIC）与一般转录因子（GTFs）的组装，后者识别启动子周围的DNA序列元件并招募Pol II。这一过程还需要多亚基中介复合体，它可以被视为转录的平台。在PIC中，两条DNA链是
Regulation of gene expression is critical in determining cell identity, development, and responses to the cellular environment. DNA is the inherited source of genetic information, and regulation of gene expression starts with selection of which genes will undergo transcription. RNA, the product of transcription, is then utilized to generate functional products, including being translated into protein or processed into functional RNA. In eukaryotes, protein coding genes are transcribed by RNA polymerase II (Pol II) into messenger RNAs (mRNA). These short-lived RNA species have a variety of characteristics and are extensively regulated from production to degradation. 1 With the assistance of methods such as those using microarrays and high-throughput sequencing, the scale and depth of Pol II transcription studies have exploded. The sheer volume and complexity of data from many sources have even triggered a call for careful rethinking of the methods used for analysis and interpretation. 2 It is doubtless, though, that regulation of transcription critically affects gene expression and thus cell state and cellular identity. 3 Pol II transcription starts with the assembly of a preinitiation complex (PIC) with general transcription factors (GTFs) that recognize DNA sequence elements around the promoter and recruit Pol II. 4 This process also requires the multisubunit Mediator complex that could be viewed as a platform for transcription. 5 In the PIC, the two strands of DNA are
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影响因子：
4.8
作者：
Adamson, TE;Shutt, DC;Price, DH
通讯作者：
Price, DH
影响因子：
10.5
作者：
Bartkowiak, Bartlomiej;Liu, Pengda;Greenleaf, Arno L.
通讯作者：
Greenleaf, Arno L.
影响因子：
16
作者：
Ahn, SH;Kim, M;Buratowski, S
通讯作者：
Buratowski, S
DOI：
10.1016/j.bbagrm.2010.01.011
发表时间：
2010-05
影响因子：
4.7
作者：
Bayfield, Mark A.;Yang, Ruiqing;Maraia, Richard J.
通讯作者：
Maraia, Richard J.
影响因子：
16.8
作者：
通讯作者：
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