Assessing the health risk of living near composting facilities on lung health, fungal and bacterial disease in cystic fibrosis: a UK CF Registry study.
Assessing the health risk of living near composting facilities on lung health, fungal and bacterial disease in cystic fibrosis: a UK CF Registry study.
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DOI：
10.1186/s12940-022-00932-1
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发表时间：
2022-12-15
影响因子：
6
通讯作者：
Piel, Frederic B.
中科院分区：
文献类型：
--
作者：
Khan, Muhammad Saleem;Douglas, Philippa;Hansell, Anna L.;Simmonds, Nicholas J.;Piel, Frederic B.
为探讨英国各地生活在允许堆肥场地（PCS）附近对囊性纤维化（CF）儿童和成人疾病严重程度的健康风险，采用半个体横断面研究方法，研究了2016年英国PCS范围内和4 km以外的CF（CF）患者的疾病严重程度风险。在英国CF登记研究中注册的所有CIMCF均符合本研究的资格。线性和泊松回归，调整年龄，性别，基因型，体重指数，铜绿假单胞菌和剥夺，用于量化PCS的距离和百分比预测用力呼气容积在一秒（ppFEV 1），肺部急性加重（#IVdays），真菌和细菌感染之间的关联。研究的9，361名CCRCF（3，931名儿童和5，430名成人）的平均年龄为20.1（SD = 14.1）岁; 53.3%为男性; 49.2%为纯合子F508 del。超过10%的pwCF（n = 1，015）居住在PCS 4公里范围内。我们发现儿童的ppFEV 1和#IV天/年无统计学显著差异。然而，在成人中，在PCS的4 km范围内，ppFEV 1降低-1.07%（95%置信区间（CI）：-2.29%，0.16%），#IV天/年增加1.02天（95% CI：1.01，1.04）。此外，患有烟曲霉菌的CF成人的平均ppFEV 1存在统计学显著差异（58.2%）。vs 62.0%，p = 0.005）和念珠菌属。(56.9% vs 59.9%，p = 0.029）居住在PCS 4 km范围内。未发现与过敏性支气管肺炎曲霉菌病、铜绿假单胞菌或金黄色葡萄球菌相关。这项新的全国性研究提供了证据，表明生活在PCS附近的CF成人可能会经历肺功能的小幅降低，肺部急性加重的风险增加，以及更频繁的真菌感染。如果使用精确的暴露评估方法对生物气溶胶分散进行研究，这些结果可能对生物气溶胶的生活环境产生重要影响。在线版本包含补充材料，可通过10.1186/s12940-022-00932-1获得。
To explore the health risk of living near permitted composting sites (PCSs) on disease severity in children and adults with cystic fibrosis (CF) across the UK. A semi-individual cross-sectional study was used to examine the risk of disease severity in people with CF (pwCF) within and beyond 4 km of PCSs in the UK in 2016. All pwCF registered in the UK CF Registry were eligible for this study. Linear and Poisson regressions, adjusted for age, gender, genotype, BMI, Pseudomonas aeruginosa and deprivation, were used to quantify associations between distance to a PCS and percent predicted forced expiratory volume in one second (ppFEV1), pulmonary exacerbations (#IVdays), and fungal and bacterial infections. The mean age of the 9,361 pwCF (3,931 children and 5,430 adults) studied was 20.1 (SD = 14.1) years; 53.3% were male; and 49.2% were homozygous F508del. Over 10% of pwCF (n = 1,015) lived within 4 km of a PCS. We found no statistically significant difference in ppFEV1 and #IVdays/year in children. However, in adults, ppFEV1 was -1.07% lower (95% confidence interval (CI): -2.29%, 0.16%) and #IVdays/year were 1.02 day higher (95%CI: 1.01, 1.04) within 4 km of a PCS. Furthermore, there were statistically significant differences in mean ppFEV1 in CF adults with Aspergillus fumigatus (58.2.% vs 62.0%, p = 0.005) and Candida spp. (56.9% vs 59.9%, p = 0.029) residing within 4 km of a PCS. No associations were identified for allergic bronchopulmonary aspergillosis, P. aeruginosa or Staphylococcus aureus. This novel national study provides evidence that adults with CF living near a PCS may experience small reductions in lung function, an increased risk of pulmonary exacerbations, and more frequent fungal infections. If confirmed by studies using refined exposure assessment methods accounting for bioaerosol dispersion, these results could have important implications for the living environment of pwCF. The online version contains supplementary material available at 10.1186/s12940-022-00932-1.
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影响因子：
3.6
作者：
Chiappini, Elena;Taccetti, Giovanni;de Martino, Maurizio
通讯作者：
de Martino, Maurizio
影响因子：
1.7
作者：
Gilligan, Peter H.
通讯作者：
Gilligan, Peter H.
影响因子：
168.9
作者：
Heijerman, Harry G. M.;McKone, Edward F.;Mccoy, Karen S.
通讯作者：
Mccoy, Karen S.
DOI：
10.1093/gerona/glv201
发表时间：
2016-07-01
影响因子：
5.1
作者：
Fragoso, Carlos A. Vaz;McAvay, Gail;Gill, Thomas M.
通讯作者：
Gill, Thomas M.
影响因子：
10.4
作者：
Mendell MJ;Mirer AG;Cheung K;Tong M;Douwes J
通讯作者：
Douwes J