Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence.
Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence.
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DOI：
10.1289/ehp.1002410
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发表时间：
2011-06
影响因子：
10.4
通讯作者：
Douwes J
中科院分区：
文献类型：
--
作者：
Mendell MJ;Mirer AG;Cheung K;Tong M;Douwes J
许多研究表明，明显的室内潮湿或霉菌与呼吸或过敏性健康影响之间存在一致的联系，但因果关系仍不清楚。关于测量的微生物因素的发现很少受到审查。我们对这些主题进行了最新的全面审查。我们回顾了截至2009年底，关于潮湿、霉菌或其他微生物制剂与呼吸或过敏反应的同行评议流行病学研究或定量荟萃分析。我们评价了潮湿或霉菌（一起考虑）的定性/主观评估与特定健康结局之间的因果关系或关联性的证据。我们分别考虑了微生物因子的特定定量测量与每种健康结果之间的关联证据。来自流行病学研究和荟萃分析的证据表明，室内潮湿或霉菌与哮喘的发生和加重、当前和以往的哮喘诊断、呼吸困难、喘息、咳嗽、呼吸道感染、支气管炎、过敏性鼻炎、湿疹和上呼吸道症状的增加一致相关。在过敏和非过敏个体中发现了相关性。有证据强烈提示儿童哮喘加重的原因。只有少数特定的测量微生物因子有提示性证据，并且部分不明确，表明与健康的不利和保护关联。明显的潮湿或霉菌与多种过敏和呼吸系统影响有一致的正相关性。粉尘中测得的微生物制剂具有有限的暗示性关联，包括某些制剂的阳性和阴性关联。因此，室内潮湿和霉菌的预防和补救可能会降低健康风险，但目前的证据并不支持测量特定的室内微生物因素来指导健康保护行动。
Many studies have shown consistent associations between evident indoor dampness or mold and respiratory or allergic health effects, but causal links remain unclear. Findings on measured microbiologic factors have received little review. We conducted an updated, comprehensive review on these topics. We reviewed eligible peer-reviewed epidemiologic studies or quantitative meta-analyses, up to late 2009, on dampness, mold, or other microbiologic agents and respiratory or allergic effects. We evaluated evidence for causation or association between qualitative/subjective assessments of dampness or mold (considered together) and specific health outcomes. We separately considered evidence for associations between specific quantitative measurements of microbiologic factors and each health outcome. Evidence from epidemiologic studies and meta-analyses showed indoor dampness or mold to be associated consistently with increased asthma development and exacerbation, current and ever diagnosis of asthma, dyspnea, wheeze, cough, respiratory infections, bronchitis, allergic rhinitis, eczema, and upper respiratory tract symptoms. Associations were found in allergic and nonallergic individuals. Evidence strongly suggested causation of asthma exacerbation in children. Suggestive evidence was available for only a few specific measured microbiologic factors and was in part equivocal, suggesting both adverse and protective associations with health. Evident dampness or mold had consistent positive associations with multiple allergic and respiratory effects. Measured microbiologic agents in dust had limited suggestive associations, including both positive and negative associations for some agents. Thus, prevention and remediation of indoor dampness and mold are likely to reduce health risks, but current evidence does not support measuring specific indoor microbiologic factors to guide health-protective actions.
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影响因子：
10.4
作者：
Dales R;Miller D;Ruest K;Guay M;Judek S
通讯作者：
Judek S
影响因子：
12.4
作者：
Douwes, J.;Travier, N.;Pearce, N.
通讯作者：
Pearce, N.
影响因子：
5.8
作者：
Fisk, W. J.;Lei-Gomez, Q.;Mendell, M. J.
通讯作者：
Mendell, M. J.
影响因子：
4.4
作者：
Górny, RL;Reponen, T;Grinshpun, SA
通讯作者：
Grinshpun, SA
影响因子：
14.2
作者：
Douwes, J;Le Gros, G;Pearce, N
通讯作者：
Pearce, N