Experimental cryosurgery investigations in vivo.

Experimental cryosurgery investigations in vivo.
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DOI:
10.1016/j.cryobiol.2009.10.001
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发表时间:
2009-12
期刊:
影响因子:
2.7
通讯作者:
Baust, J. G.
Baust, J. G.
中科院分区:
生物学3区
文献类型:
--
作者:
Gage, A. A.;Baust, J. M.;Baust, J. G.

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冷冻手术是利用冷冻温度在目标组织中引起消融反应。这篇综述提供了一个全球性的概述,在体内的实验一直是这个广泛应用的治疗选择的进步的基础。细胞和组织相关的事件,破坏的机制,包括直接的细胞损伤(冷冻),血管淤滞,细胞凋亡和坏死的基础上,进行了描述,并与冷冻技术的最佳方法,以实现有效的治疗。主要器官的体内实验,包括伤口愈合,解冻后的假定免疫反应,以及使用冷冻策略来增强癌细胞对冷冻的敏感性。
Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue. This review provides a global overview of experimentation in vivo which has been the basis of advancement of this widely applied therapeutic option. The cellular and tissue-related events that underlie the mechanisms of destruction, including direct cell injury (cryolysis), vascular stasis, apoptosis and necrosis, are described and are related to the optimal methods of technique of freezing to achieve efficacious therapy. In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described.
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发表时间: 1993-10-01
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