Urinary Sodium Excretion Enhances the Effect of Alcohol on Blood Pressure.
Urinary Sodium Excretion Enhances the Effect of Alcohol on Blood Pressure.
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DOI：
10.3390/healthcare10071296
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发表时间：
2022-07-13
期刊：
影响因子：
2.8
通讯作者：
Pazoki, Raha
中科院分区：
文献类型：
--
作者：
Jiang, Xiyun;Anasanti, Mila D.;Drenos, Fotios;Blakemore, Alexandra, I;Pazoki, Raha
饮酒与尿钠排泄有关，这两种特征都与高血压和心血管疾病（CVD）有关。饮酒和钠对高血压和心血管疾病（CVD）的相互作用尚未得到充分描述。在这里，我们使用基因预测的酒精消费量，并探讨酒精消费量，尿钠，高血压和心血管疾病之间的关系。研究方法：我们对来自英国生物银行前瞻性队列的295，189名参与者进行了比较分析（基线数据收集于2006年至2010年）。我们使用105种已发表的与饮酒相关的欧洲人遗传变异创建了遗传风险评分（GRS）。我们探讨了GRS、饮酒、尿钠、血压特征和心血管事件之间的关系。在我们的分析中，我们使用线性和逻辑回归和考克斯比例风险（PH）模型和孟德尔随机化。结果：复合心血管疾病和卒中的中位随访时间分别为6.1年和7.1年。我们的分析表明，大量饮酒与低尿钠排泄有关。我们的研究结果表明，高酒精GRS与高血压和中风风险增加有关，并支持酒精GRS和尿钠对2级高血压（P相互作用= 0.03）和CVD（P相互作用= 0.03）的相互作用，即，在高尿钠排泄的情况下，酒精GRS对血压的影响可能会增强。结论：我们的研究结果表明，尿钠排泄可能抵消饮酒遗传风险带来的风险。
Alcohol consumption is linked to urinary sodium excretion and both of these traits are linked to hypertension and cardiovascular diseases (CVDs). The interplay between alcohol consumption and sodium on hypertension, and cardiovascular diseases (CVDs) is not well-described. Here, we used genetically predicted alcohol consumption and explored the relationships between alcohol consumption, urinary sodium, hypertension, and CVDs. Methods: We performed a comparative analysis among 295,189 participants from the prospective cohort of the UK Biobank (baseline data collected between 2006 and 2010). We created a genetic risk score (GRS) using 105 published genetic variants in Europeans that were associated with alcohol consumption. We explored the relationships between GRS, alcohol consumption, urinary sodium, blood pressure traits, and incident CVD. We used linear and logistic regression and Cox proportional hazards (PH) models and Mendelian randomization in our analysis. Results: The median follow-up time for composite CVD and stroke were 6.1 years and 7.1 years respectively. Our analyses showed that high alcohol consumption is linked to low urinary sodium excretion. Our results showed that high alcohol GRS was associated with high blood pressure and higher risk of stroke and supported an interaction effect between alcohol GRS and urinary sodium on stage 2 hypertension (Pinteraction = 0.03) and CVD (Pinteraction = 0.03), i.e., in the presence of high urinary sodium excretion, the effect of alcohol GRS on blood pressure may be enhanced. Conclusions: Our results show that urinary sodium excretion may offset the risk posed by genetic risk of alcohol consumption.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
酒精摄入和血压：实施孟德尔随机方法的系统评价。
影响因子：
15.8
作者：
Chen L;Smith GD;Harbord RM;Lewis SJ
通讯作者：
Lewis SJ
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
DOI：
10.1097/ede.0000000000000559
发表时间：
2017-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Burgess S;Bowden J;Fall T;Ingelsson E;Thompson SG
通讯作者：
Thompson SG
影响因子：
168.9
作者：
Millwood, Iona Y.;Walters, Robin G.;Chen, Zhengming
通讯作者：
Chen, Zhengming