Severe acute respiratory syndrome (SARS): epidemiology and clinical features.

Severe acute respiratory syndrome (SARS): epidemiology and clinical features.
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DOI:
10.1136/pgmj.2004.020263
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发表时间:
2004-07
影响因子:
5.1
通讯作者:
Ng PC
Ng PC
中科院分区:
医学4区
文献类型:
--
作者:
Hui DS;Chan MC;Wu AK;Ng PC

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严重急性呼吸综合征(severeacuterespiratorysyndrome,SARS)是一种新发传染病,发病率和死亡率都很高。主要临床特征包括持续发热、寒战/寒战、肌痛、不适、干咳、头痛和呼吸困难。老年受试者可能没有典型的发热反应。常见的实验室特征包括淋巴细胞减少症、血小板减少症、丙氨酸转氨酶、乳酸脱氢酶和肌酸激酶升高。临床和实验室检查结果一致,加上某些特征性的放射学特征和对广谱抗生素缺乏临床反应,应引起对SARS的怀疑。用真实的时间反转录-聚合酶链反应技术测定血清RNA,在发病第一周内的检出率为75%~ 80%。
Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with a significant morbidity and mortality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache, and dyspnoea. Older subjects may present without the typical febrile response. Common laboratory features include lymphopenia, thrombocytopenia, raised alanine transaminases, lactate dehydrogenase, and creatine kinase. The constellation of compatible clinical and laboratory findings, together with certain characteristic radiological features and lack of clinical response to broad spectrum antibiotics, should arouse suspicion of SARS. Measurement of serum RNA by real time reverse transcriptase-polymerase chain reaction technique has a detection rate of 75%–80% in the first week of the illness.
DOI: 10.1016/s0140-6736(03)13967-0
发表时间: 2003-07-26
期刊: Lancet (London, England)
影响因子: --
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