Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances.
Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances.
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DOI：
10.3390/s18103249
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发表时间：
2018-09-27
期刊：
影响因子：
--
通讯作者：
Huang H
中科院分区：
文献类型：
--
作者：
Huang H
作为研究最广泛的基质金属蛋白酶(MMPs)之一，MMP9是一种重要的蛋白水解酶，在许多生物过程中发挥着重要作用。基质金属蛋白酶-9可裂解多种细胞外基质蛋白，调节细胞外基质重塑。它还可以裂解许多血浆表面蛋白，将它们从细胞表面释放出来。基质金属蛋白酶-9已被广泛发现与癌症的病理有关，包括但不限于侵袭、转移和血管生成。最近的一些研究评估了基质金属蛋白酶-9作为各种特定癌症的生物标志物的价值。此外，最近对基质金属蛋白酶-9生物传感器的研究发现了各种新型的基质金属蛋白酶-9生物传感器来检测这种酶。本文综述了近年来基质金属蛋白酶-9作为生物标记物在不同肿瘤中的研究进展，并介绍了新型基质金属蛋白酶-9生物传感器的最新发现。
As one of the most widely investigated matrix metalloproteinases (MMPs), MMP-9 is a significant protease which plays vital roles in many biological processes. MMP-9 can cleave many extracellular matrix (ECM) proteins to regulate ECM remodeling. It can also cleave many plasma surface proteins to release them from the cell surface. MMP-9 has been widely found to relate to the pathology of cancers, including but not limited to invasion, metastasis and angiogenesis. Some recent research evaluated the value of MMP-9 as biomarkers to various specific cancers. Besides, recent research of MMP-9 biosensors discovered various novel MMP-9 biosensors to detect this enzyme. In this review, some recent advances in exploring MMP-9 as a biomarker in different cancers are summarized, and recent discoveries of novel MMP-9 biosensors are also presented.
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影响因子：
11.2
作者：
Chakraborty, Subhankar;Kaur, Sukhwinder;Guha, Sushovan;Batra, Surinder K.
通讯作者：
Batra, Surinder K.
影响因子：
11.2
作者：
Garg P;Sarma D;Jeppsson S;Patel NR;Gewirtz AT;Merlin D;Sitaraman SV
通讯作者：
Sitaraman SV
影响因子：
4.7
作者：
Fan, Dongmei;Wang, Ying;Tian, Xiaoyu
通讯作者：
Tian, Xiaoyu
DOI：
10.3390/pathogens2010105
发表时间：
2013-02-19
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Bruschi F;Pinto B
通讯作者：
Pinto B
影响因子：
4
作者：
Chen, Liang;Zhang, Ji;Ding, Xiao-Yi
通讯作者：
Ding, Xiao-Yi