The role of STAT3 in leading the crosstalk between human cancers and the immune system.
The role of STAT3 in leading the crosstalk between human cancers and the immune system.
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STAT3 在引导人类癌症和免疫系统之间的串扰中的作用。
DOI：
10.1016/j.canlet.2017.12.003
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发表时间：
2018-02-28
期刊：
影响因子：
9.7
通讯作者：
Zhou X
中科院分区：
文献类型：
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作者：
Wang Y;Shen Y;Wang S;Shen Q;Zhou X
人类癌症的发生和发展受到内在和外在因素的持续、动态调控。作为多种致癌途径的交汇点，信号转导器和转录激活剂 3 (STAT3) 在肿瘤细胞和肿瘤浸润的免疫细胞中均被组成型激活。激活的 STAT3 通过直接调节致癌基因表达持续触发肿瘤进展。除了调节肿瘤细胞基因表达的致癌作用外，STAT3 还通过免疫抑制为人类癌症的生长铺平了道路。免疫细胞中激活的 STAT3 会抑制免疫介质并促进免疫抑制因子的产生。因此，STAT3调节肿瘤细胞与宿主免疫之间的相互作用。越来越多的证据表明，靶向 STAT3 可能会增强抗癌免疫反应并挽救肿瘤中受抑制的免疫微环境。总而言之，STAT3 已成为癌症免疫治疗中一个有前途的靶点。
The development and progression of human cancers are continuously and dynamically regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic pathways, signal transducer and activator of transcription 3 (STAT3) is constitutively activated both in tumor cells and tumor-infiltrated immune cells. Activated STAT3 persistently triggers tumor progression through direct regulation of oncogenic gene expression. Apart from its oncogenic role in regulating gene expression in tumor cells, STAT3 also paves the way for human cancer growth through immunosuppression. Activated STAT3 in immune cells results in inhibition of immune mediators and promotion of immunosuppressive factors. Therefore, STAT3 modulates the interaction between tumor cells and host immunity. Accumulating evidence suggests that targeting STAT3 may enhance anti-cancer immune responses and rescue the suppressed immunologic microenvironment in tumors. Taken together, STAT3 has emerged as a promising target in cancer immunotherapy.
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影响因子：
4.2
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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