Roles of the immune system in skin cancer.
Roles of the immune system in skin cancer.
复制标题
DOI：
10.1111/j.1365-2133.2011.10507.x
复制
发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Tsai KY
中科院分区：
文献类型：
--
作者：
Rangwala S;Tsai KY
在过去的几十年里，人们越来越关注免疫系统在癌症发展和进展中的作用。免疫系统在人类皮肤癌中的重要性早已被认识到，主要是基于器官移植受者皮肤癌发病率的增加和紫外线介导的免疫调节机制。在这篇综述中，我们整合了多条证据线，突出了免疫系统在皮肤癌中的作用。首先，我们讨论癌症免疫监视和免疫编辑的概念，因为它们可能与人类皮肤癌有关。然后，我们描述了皮肤癌的发展和进展的临床和分子机制的背景下，治疗性免疫抑制在器官移植受者，病毒致癌，紫外线诱导的免疫调节，主要集中在基底细胞癌和鳞状细胞癌。还描述了支持免疫疗法扩大作用的临床证据。最后，我们讨论了最近的研究检查皮肤癌中特定免疫细胞亚群的功能，以及它们如何有助于抗肿瘤和促肿瘤作用。更好地理解癌症免疫监视的生物学机制有望实现更好的治疗。
Over the past several decades, there has been increasing interest in understanding the roles of the immune system in the development and progression of cancer. The importance of the immune system in human skin cancer has been long recognised based primarily upon the increased incidence of skin cancers in organ transplant recipients and mechanisms of ultraviolet light-mediated immunomodulation. In this review, we integrate multiple lines of evidence highlighting the roles of the immune system in skin cancer. First, we discuss the concepts of cancer immunosurveillance and immunoediting as they might relate to human skin cancers. We then describe the clinical and molecular mechanisms of skin cancer development and progression in the contexts of therapeutic immunosuppression in organ transplant recipients, viral oncogenesis, and ultraviolet light-induced immunomodulation with a primary focus on basal cell carcinoma and squamous cell carcinoma. The clinical evidence supporting expanding roles for immunotherapy is also described. Finally, we discuss recent research examining the functions of particular immune cell subsets in skin cancer and how they might contribute to both anti-tumour and pro-tumour effects. A better understanding of the biological mechanisms of cancer immunosurveillance holds the promise of enabling better therapies.
登录
查看更多内容
影响因子：
2
作者：
Borghi-Cirri, MB;Riccardi-Arbi, R;Filipponi, F
通讯作者：
Filipponi, F
影响因子：
0.9
作者：
Bichari, W.;Bartiromo, M.;Berthoux, F.
通讯作者：
Berthoux, F.
影响因子：
6.2
作者：
Bavinck, JNB;Hardie, DR;Hardie, IR
通讯作者：
Hardie, IR
影响因子：
--
作者：
ADAMI, J;FRISCH, M;MELBYE, M
通讯作者：
MELBYE, M
影响因子：
56.9
作者：
Brunn, GJ;Hudson, CC;Abraham, RT
通讯作者：
Abraham, RT