The Involvement of Mg(2+) in Regulation of Cellular and Mitochondrial Functions.

The Involvement of Mg(2+) in Regulation of Cellular and Mitochondrial Functions.
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DOI:
10.1155/2017/6797460
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发表时间:
2017
影响因子:
--
通讯作者:
Racay P
Racay P
中科院分区:
生物学2区
文献类型:
--
作者:
Pilchova I;Klacanova K;Tatarkova Z;Kaplan P;Racay P

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Mg 2+是一种必需的矿物质,对细胞生理和功能具有多向性影响。它作为几种重要酶的辅因子,作为离子通道(如电压依赖性Ca 2+通道和K+通道)的调节剂,并作用于Ca 2+结合蛋白。Ca ~(2+)是启动或调节多种细胞功能的重要第二信使,Mg ~(2+)被认为是Ca ~(2+)的主要胞内拮抗剂。本文综述了Mg 2+对线粒体功能的影响,特别关注能量代谢,线粒体Ca 2+处理和细胞凋亡。
Mg2+ is an essential mineral with pleotropic impacts on cellular physiology and functions. It acts as a cofactor of several important enzymes, as a regulator of ion channels such as voltage-dependent Ca2+ channels and K+ channels and on Ca2+-binding proteins. In general, Mg2+ is considered as the main intracellular antagonist of Ca2+, which is an essential secondary messenger initiating or regulating a great number of cellular functions. This review examines the effects of Mg2+ on mitochondrial functions with a particular focus on energy metabolism, mitochondrial Ca2+ handling, and apoptosis.
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