Extracellular Vesicles: A More Layer of the Complexity of Hydatid Fluid Contents and Functions
Extracellular Vesicles: A More Layer of the Complexity of Hydatid Fluid Contents and Functions
复制标题
细胞外囊泡：包虫液体内容和功能的更复杂性
DOI：
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Juntao DING
中科院分区：
文献类型：
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作者：
Yixia CHEN;Juntao DING
he discovery of extracellular vesicles (EVs) makes the hydatid fluid (HF) contents more complex. First, EVs are composed of a diversity of active molecules, including proteins, lipids, mRNAs and noncoding RNAs. Although the encapsulated components have yet to be fully deciphered, parasite EVs have been shown to contain a considerable number of different proteins, most of which are absent in the HF (1, 2). More importantly, parasites can secrete nucleic acids especially miRNAs into EVs, demonstrated to be active in modulation of gene expression in receipt cells (3). Second, EV secretion and composition of EV contents are highly dynamic, and show differences under distinct physiological and pathophysiological settings. In addition, different types of cells or tissues secrete EVs harboring different molecules (4). From these points, the HF EVs should be the mixture of EVs mainly released by hydatid cyst cells, brood capsules and free protoscoleces (1). They are postulated to be distinct at different infectious and developmental stages of E. granulosus metacestodes. Third, EVs have two main subtypes-exosomes and ectosomes. The two EV subpopulations show differences in the biogenesis, size and contents. Despite these differences, released exosomes and ectosomes function in a similar way (4). It is also becoming clear that the EV contents change with the mode of biogenesis. Due to the shedding of ectosomes usually responding to external signals, it is interesting to determine them in the HF in further studies, which will be helpful to uncover the complexity of HF EVs. Fourth, host proteins were reported to be present in preparations of paraT Iranian Society of Parasitology http://isp.tums.ac.ir Iran J Parasitol
影响因子：
4
作者：
dos Santos, Guilherme B.;Monteiro, Karina M.;Zaha, Arnaldo
通讯作者：
Zaha, Arnaldo
影响因子：
2.6
作者：
Siles-Lucas, Mar;Sanchez-Ovejero, Carlos;Manzano-Romana, Raul
通讯作者：
Manzano-Romana, Raul
线虫寄生虫分泌的外泌体将小的RNA转移到哺乳动物细胞上并调节先天免疫。
影响因子：
16.6
作者：
Buck, Amy H.;Coakley, Gillian;Simbari, Fabio;McSorley, Henry J.;Quintana, Juan F.;Le Bihan, Thierry;Kumar, Sujai;Abreu-Goodger, Cei;Lear, Marissa;Harcus, Yvonne;Ceroni, Alessandro;Babayan, Simon A.;Blaxter, Mark;Ivens, Alasdair;Maizels, Rick M.
通讯作者：
Maizels, Rick M.