Genetic variants in vitamin D metabolism-related genes and body mass index: analysis of genome-wide scan data of approximately 7000 Chinese women.
Genetic variants in vitamin D metabolism-related genes and body mass index: analysis of genome-wide scan data of approximately 7000 Chinese women.
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DOI：
10.1038/ijo.2011.246
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发表时间：
2012-09
影响因子：
4.9
通讯作者：
Shu, X. O.
中科院分区：
文献类型：
--
作者：
Dorjgochoo, T.;Shi, J.;Gao, Y-T;Long, J.;Delahanty, R.;Xiang, Y-B;Cai, Q.;Shu, X. O.
维生素D缺乏一直与肥胖联系在一起。然而，目前尚不清楚维生素D缺乏是肥胖的原因还是后果。我们通过评估维生素D代谢途径基因的遗传变异与肥胖相关特征之间的关联来研究这个问题。利用对6922名年龄在25-70岁的女性进行的全基因组关联(GWA)研究的直接基因分型和输入数据，我们研究了维生素D途径基因(CYP27A1、CYP27B1、CYP24A1、CYP2R1、GC和VDR)的198个SNP与体重指数(BMI)和体重的关系。使用线性回归模型计算这种关联的每等位基因β(β)估计值，控制了年龄、年龄平方、绝经状态和样本量。总体而言，只有两个SNP(CYP24A1中的rs2248359和CYP2R1中的rs10832313)与BMI和体重有名义上的显著关联(P=0.02)，并且没有观察到绝经状态、体力活动或饮食能量摄入的变化。在VDR基因中检测到的SNP与BMI或体重无关。我们的发现表明，维生素D途径基因的常见遗传变异在中国女性肥胖中并不起主要作用。
Vitamin D deficiency has been consistently associated with obesity. However, it is unclear whether vitamin D deficiency is the cause or consequence of obesity. We investigated this question by evaluating the association between genetic variants in vitamin D metabolism pathway genes and obesity-related traits. Using directly genotyped and imputed data from a genome-wide association (GWA) study of 6,922 women aged 25–70 years, we examined the association of 198 SNPs in vitamin D pathway genes (CYP27A1, CYP27B1, CYP24A1, CYP2R1, GC, and VDR) with body mass index (BMI) and body weight. Per allele beta (β) estimates were calculated for this association using linear regression models, controlling for age, square of age, menopausal status, and sample sets. Overall, only two SNPs (rs2248359 in CYP24A1 and rs10832313 in CYP2R1) had a nominally significant association with BMI and weight (P=0.02 for both) with no variation observed by menopausal status, physical activity, or dietary energy intake. None of the SNPs examined in the VDR gene were associated with BMI or weight. Our findings suggest that common genetic variations in vitamin D pathway genes do not play a major role in obesity among Chinese women.
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影响因子：
4.5
作者：
Shu XO;Long J;Cai Q;Qi L;Xiang YB;Cho YS;Tai ES;Li X;Lin X;Chow WH;Go MJ;Seielstad M;Bao W;Li H;Cornelis MC;Yu K;Wen W;Shi J;Han BG;Sim XL;Liu L;Qi Q;Kim HL;Ng DP;Lee JY;Kim YJ;Li C;Gao YT;Zheng W;Hu FB
通讯作者：
Hu FB
影响因子：
30.8
作者：
Zheng, Wei;Long, Jirong;Gao, Yu-Tang;Li, Chun;Zheng, Ying;Xiang, Yong-Bin;Wen, Wanqing;Levy, Shawn;Deming, Sandra L.;Haines, Jonathan L.;Gu, Kai;Fair, Alecia Malin;Cai, Qiuyin;Lu, Wei;Shu, Xiao-Ou
通讯作者：
Shu, Xiao-Ou
影响因子：
3.5
作者：
Ahn J;Yu K;Stolzenberg-Solomon R;Simon KC;McCullough ML;Gallicchio L;Jacobs EJ;Ascherio A;Helzlsouer K;Jacobs KB;Li Q;Weinstein SJ;Purdue M;Virtamo J;Horst R;Wheeler W;Chanock S;Hunter DJ;Hayes RB;Kraft P;Albanes D
通讯作者：
Albanes D
影响因子：
168.9
作者：
Wang, Thomas J.;Zhang, Feng;Richards, J. Brent;Kestenbaum, Bryan;van Meurs, Joyce B.;Berry, Diane;Kiel, Douglas P.;Streeten, Elizabeth A.;Ohlsson, Claes;Koller, Daniel L.;Peltonen, Leena;Cooper, Jason D.;O'Reilly, Paul F.;Houston, Denise K.;Glazer, Nicole L.;Vandenput, Liesbeth;Peacock, Munro;Shi, Julia;Rivadeneira, Fernando;McCarthy, Mark I.;Anneli, Pouta;de Boer, Ian H.;Mangino, Massimo;Kato, Bernet;Smyth, Deborah J.;Booth, Sarah L.;Jacques, Paul F.;Burke, Greg L.;Goodarzi, Mark;Cheung, Ching-Lung;Wolf, Myles;Rice, Kenneth;Goltzman, David;Hidiroglou, Nick;Ladouceur, Martin;Wareham, Nicholas J.;Hocking, Lynne J.;Hart, Deborah;Arden, Nigel K.;Cooper, Cyrus;Malik, Suneil;Fraser, William D.;Hartikainen, Anna-Liisa;Zhai, Guangju;Macdonald, Helen M.;Forouhi, Nita G.;Loos, Ruth J. F.;Reid, David M.;Hakim, Alan;Dennison, Elaine;Liu, Yongmei;Power, Chris;Stevens, Helen E.;Jaana, Laitinen;Vasan, Ramachandran S.;Soranzo, Nicole;Bojunga, Joerg;Psaty, Bruce M.;Lorentzon, Mattias;Foroud, Tatiana;Harris, Tamara B.;Hofman, Albert;Jonsson, John-Olov;Cauley, Jane A.;Uitterlinden, Andre G.;Gibson, Quince;Jarvelin, Marjo-Riitta;Karasik, David;Siscovick, David S.;Econs, Michael J.;Kritchevsky, Stephen B.;Florez, Jose C.;Todd, John A.;Dupuis, Josee;Hyppoenen, Elina;Spector, Timothy D.
通讯作者：
Spector, Timothy D.
影响因子：
2
作者：
Tworowska-Bardzinska, Urszula;Lwow, Felicja;Milewicz, Andrzej
通讯作者：
Milewicz, Andrzej