Oxytocin administration versus emotion training in healthy males: considerations for future research.
Oxytocin administration versus emotion training in healthy males: considerations for future research.
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DOI：
10.1098/rstb.2021.0056
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发表时间：
2022-08-29
期刊：
影响因子：
--
通讯作者：
van Goozen S
中科院分区：
文献类型：
--
作者：
Daughters K;Rees DA;Hunnikin L;Wells A;Hall J;van Goozen S
正确识别情绪对于成功的社交互动至关重要。因此，人们对设计治疗干预措施以改善社交互动困难的个体的情绪识别产生了浓厚的兴趣。神经肽催产素因其在情绪识别和社会认知的其他方面的重要作用而被提议作为一种潜在的生理干预措施。然而，目前文献中常用的鼻内催产素形式有许多注意事项需要考虑。另一方面，心理干预则没有同样的注意事项，因此有必要了解鼻内催产素给药与旨在针对相同心理现象的心理干预相比如何；以及联合干预方法是否可以提供附加效益。在这里，我们在健康志愿者中进行了一项试点概念验证研究，比较了鼻内催产素与经过验证的情绪训练计划的效果，发现心理干预（而不是鼻内催产素）可以改善情绪识别，特别是针对愤怒表达。我们讨论该研究对未来临床试验的理论意义。本文是主题“催产素和其他神经调节剂在塑造复杂社会行为中的相互作用”的一部分。
Identifying emotions correctly is essential for successful social interaction. There is therefore a keen interest in designing therapeutic interventions to improve emotion recognition in individuals who struggle with social interaction. The neuropeptide oxytocin has been proposed as a potential physiological intervention due to its important role in emotion recognition and other aspects of social cognition. However, there are a number of caveats to consider with the current form of intranasal oxytocin commonly used in the literature. Psychological interventions, on the other hand, do not carry the same caveats, and there is, therefore, a need to understand how intranasal oxytocin administration compares to psychological interventions designed to target the same psychological phenomena; and whether a combined intervention approach may provide additive benefits. Here we present a pilot, proof-of-concept study in healthy volunteers comparing the effect of intranasal oxytocin against a validated emotion training programme, finding that the psychological intervention, and not intranasal oxytocin, improved emotion recognition specifically for angry expressions. We discuss the theoretical implications of the research for future clinical trials. This article is part of the theme issue ‘Interplays between oxytocin and other neuromodulators in shaping complex social behaviours’.
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