Case report: ZEB1 expression in three cases of hepatic carcinosarcoma.
Case report: ZEB1 expression in three cases of hepatic carcinosarcoma.
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DOI：
10.3389/fonc.2022.972650
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发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
肝癌肉瘤（HCS）定义为包含上皮癌和间叶组织肉瘤的肿瘤。HCS发病率低，包括骨肉瘤、软骨肉瘤或血管肉瘤。虽然手术是HCS的主要治疗方法，但其效果并不理想，导致HCS的预后非常差。目前，关于HCS的报道主要是对临床病理现象、影像学特征和相关基因突变位点的描述，HCS的潜在分子机制尚未明确。通过上皮-间充质转化（EMT）的动态过程，癌细胞获得间充质表型，同时失去上皮特性。锌指E-box binding homeobox 1（ZEB 1）是一种EMT诱导转录因子，其主要调控靶点是E-cadherin。食管癌肉瘤（ECS）与EMT相关。目前的研究表明，EMT可能促进ECS和子宫癌肉瘤（UCS）的发展，ZEB 1在肉瘤成分中高表达。本研究收集了3例病例，并与相应病例的临床病理特征进行了比较。免疫组化法检测ZEB 1的表达水平及亚细胞定位。ZEB 1在细胞核中的表达在所有三个病例中肉瘤成分中均显著高于癌成分，表明HCS与EMT相关。
Hepatic carcinosarcoma (HCS) is defined as a tumor that contains cancer from the epithelium and sarcoma from mesenchymal tissue. HCS has a low incidence rate and is composed of osteosarcoma, chondrosarcoma, or angiosarcoma. Though surgery is the main treatment for HCS, it has proven unsatisfactory, resulting in a very poor prognosis of HCS. Currently, the reports on HCS are mainly about the description of clinical pathological phenomena, imaging features, and mutation sites of related genes, the underlying molecular mechanism of HCS remains undefined. Through the dynamic process of epithelial-mesenchymal transition (EMT), cancer cells acquire a mesenchymal phenotype, simultaneously losing epithelial properties. Zinc finger E-box binding homeobox 1 (ZEB1) is an EMT-inducing transcription factor; its main regulatory target is E-cadherin in EMT process. Esophageal carcinosarcoma (ECS) is associated with EMT. The current study showed that EMT might promote the development of ECS and uterine carcinosarcoma (UCS), and ZEB1 was highly expressed in the sarcomatous components. In the current study, three cases were collected, and the clinicopathological features were compared with those of corresponding cases. The expression level, and subcellular localization of ZEB1 were detected using immunohistochemistry. The expression of the ZEB1 in the nucleus was found to be significantly higher in sarcomatous components than that in cancer components in all three cases, suggesting an association of HCS with EMT.
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影响因子：
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发表时间：
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期刊：
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发表时间：
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