Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back.
Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back.
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DOI：
10.1093/nar/gkaa1126
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发表时间：
2020-12-16
影响因子：
14.9
通讯作者：
Ivanov P
中科院分区：
文献类型：
--
作者：
Kharel P;Becker G;Tsvetkov V;Ivanov P
鸟嘌呤-四链体（G4）是可在富含鸟嘌呤（G）的核酸序列中形成的非典型四链结构。基于体外分析，已经描述了大量能够形成G4结构的富含G的序列，并且支持它们在活细胞中形成的证据继续积累。虽然不同的化学、成像和基因组方法都支持体内染色质内DNA G4（dG 4）的形成，但体内RNA G4（rG 4）的形成仍然是一个讨论的问题。最近的数据支持G4在转录组中形成的动态性质。rG 4折叠-展开的这种动态波动支持了这些结构在RNA代谢调节中的生物学意义。此外，rG 4介导的功能可能最终与疾病病理学的潜在机制有关，并可能为治疗提供新的选择。在这个框架中，我们将审查rG 4在转录组内的景观，专注于它们对生物过程的潜在影响，并考虑这些功能在人类健康和疾病中的新兴联系。
Guanine-quadruplexes (G4s) are non-canonical four-stranded structures that can be formed in guanine (G) rich nucleic acid sequences. A great number of G-rich sequences capable of forming G4 structures have been described based on in vitro analysis, and evidence supporting their formation in live cells continues to accumulate. While formation of DNA G4s (dG4s) within chromatin in vivo has been supported by different chemical, imaging and genomic approaches, formation of RNA G4s (rG4s) in vivo remains a matter of discussion. Recent data support the dynamic nature of G4 formation in the transcriptome. Such dynamic fluctuation of rG4 folding-unfolding underpins the biological significance of these structures in the regulation of RNA metabolism. Moreover, rG4-mediated functions may ultimately be connected to mechanisms underlying disease pathologies and, potentially, provide novel options for therapeutics. In this framework, we will review the landscape of rG4s within the transcriptome, focus on their potential impact on biological processes, and consider an emerging connection of these functions in human health and disease.
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影响因子：
8.8
作者：
Benhalevy D;Gupta SK;Danan CH;Ghosal S;Sun HW;Kazemier HG;Paeschke K;Hafner M;Juranek SA
通讯作者：
Juranek SA
影响因子：
46.9
作者：
Chambers, Vicki S.;Marsico, Giovanni;Balasubramanian, Shankar
通讯作者：
Balasubramanian, Shankar
DOI：
10.3390/molecules23092341
发表时间：
2018-09-13
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Brázda V;Červeň J;Bartas M;Mikysková N;Coufal J;Pečinka P
通讯作者：
Pečinka P
影响因子：
4.6
作者：
Bartas, Martin;Cutova, Michaela;Pecinka, Petr
通讯作者：
Pecinka, Petr
影响因子：
--
作者：
Arachchilage, Gayan Mirihana;Dassanayake, Arosha C.;Basu, Soumitra
通讯作者：
Basu, Soumitra