Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice.
Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice.
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DOI：
10.1016/j.jpain.2009.12.004
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Quock RM
中科院分区：
文献类型：
--
作者：
Chung E;Zelinski LM;Ohgami Y;Shirachi DY;Quock RM
高压氧（HBO 2）治疗被FDA批准用于有限的临床适应症，但据报道，在几种慢性疼痛疾病中可以缓解疼痛。然而，没有研究来解释HBO 2的这种明显的镇痛作用。在我们实验室进行的研究表明，每天4次60分钟的HBO 2治疗在3.5 ATA诱导了无与伦比的抗伤害反应，包括1）早期阶段，持续至少6小时后HBO 2治疗消散;和2）晚期阶段，出现约18小时后的早期阶段，并持续长达三周。早期对急性侧脑室注射（i. c. v.）给予阿片样物质拮抗剂纳洛酮和一氧化氮合酶（NOS）抑制剂L-NAME。在4次HBO 2治疗期间，通过静脉注射纳洛酮或L-NAME治疗可抑制晚期相，但在HBO 2治疗后两周急性预处理后，纳洛酮或L-NAME均未拮抗晚期相。这些实验结果暗示了一种新的机制，该机制被HBO 2激活，导致异常长时间的抗伤害性反应，这在疼痛的临床管理中具有潜在的意义。高压氧治疗小鼠可诱导持续时间异常长的双相抗伤害性反应。一氧化氮和阿片受体似乎启动或介导两个阶段的抗伤害性反应。进一步阐明潜在的机制可能会潜在地确定导致内源性镇痛系统持久激活的分子靶点。
Hyperbaric oxygen (HBO2) therapy is approved by the FDA for limited clinical indications but is reported to produce pain relief in several chronic pain conditions. However, there have been no studies to explain this apparent analgesic effect of HBO2. Research conducted in our laboratory demonstrates that four daily 60-min HBO2 treatments at 3.5 ATA induced an unparalleled antinociceptive response that consists of 1) an early phase that lasted at least six hours after the HBO2 treatment before dissipating; and 2) a late phase that emerged about 18 hours after the early phase and lasted for up to three weeks. The early phase was sensitive to antagonism by acutely intracerebroventricular (i.c.v.)-administered opioid antagonist naltrexone and the nitric oxide synthase (NOS)-inhibitor L-NAME. The late phase was inhibited by treatment with i.c.v. naltrexone or L-NAME during the four HBO2 treatments but was not antagonized by either naltrexone or L-NAME following acute pretreatment two weeks after HBO2 treatment. These experimental results implicate a novel mechanism that is activated by HBO2, resulting in an antinociceptive response of unusually long duration that is of potential interest in the clinical management of pain. Hyperbaric oxygen treatment of mice can induce a two-phase antinociceptive response of unusually long duration. Nitric oxide and opioid receptors appear to initiate or mediate both phases of the antinociceptive response. Further elucidation of the underlying mechanism may potentially identify molecular targets that cause long-lasting activation of endogenous analgesic systems.
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影响因子：
6.6
作者：
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通讯作者：
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作者：
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