Cardiac volume receptor reflex in borderline hypertensive rats.
Cardiac volume receptor reflex in borderline hypertensive rats.
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临界高血压大鼠的心脏容量受体反射。
DOI:
10.1161/01.hyp.21.2.222
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发表时间:
1993
期刊:
影响因子:
--
通讯作者:
Jones,SY
中科院分区:
文献类型:
--
作者:
DiBona,GF;Jones,SY
With increased dietary NaCl intake (8% NaCl), borderline hypertensive rats (BHR) develop hypertension and exhibit an exaggerated natriuresis in response to intravenous isotonic saline volume expansion. The exaggerated natriuresis is mediated by the concurrent exaggerated withdrawal of efferent renal sympathetic nerve activity since prior renal denervation eliminates the exaggerated natriuretic response. It was the objective of the present study to examine cardiac volume receptor reflex control of efferent renal sympathetic nerve activity in BHR made hypertensive by increased dietary NaCl intake. BHR were fed either 1% or 8% NaCl from age 4 to 16 weeks. BHR fed 8% NaCl were hypertensive (148 +/- 9 mmHg) compared with BHR fed 1% NaCl (115 +/- 6 mm Hg, p < 0.05). In one protocol, measurements of right atrial pressure and efferent renal sympathetic nerve activity were made in sinoaortic-denervated BHR before and during a 10% body weight intravenous isotonic saline volume load. Compared with 1% NaCl BHR, 8% NaCl BHR showed both a greater maximal inhibition of efferent renal sympathetic nerve activity (-67 +/- 4% versus -31 +/- 3% of control, p < 0.05) and gain (-22.0 +/- 2.3 versus -9.7 +/- 1.7%/mm Hg, p < 0.05). In a second protocol, measurements of efferent renal sympathetic nerve activity were made in sinoaortic-denervated BHR before and during graded frequency stimulation of the central portion of the sectioned vagus nerve.(ABSTRACT TRUNCATED AT 250 WORDS)
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DOI:
10.1152/ajpregu.1987.252.4.r687
发表时间:
1987
期刊:
The American journal of physiology
影响因子:
--
作者:
Dibona,GF;Sawin,LL
通讯作者:
Sawin,LL
DOI:
--
发表时间:
2006
期刊:
総務省統計研修所 リサーチペーパー 第5号
影响因子:
--
作者:
元山 斉;山口 幸三;ryoko Morozumi;美添泰人・荒木万寿夫
通讯作者:
美添泰人・荒木万寿夫
DOI:
--
发表时间:
1980
期刊:
Acta Physiologica Scandinavica
影响因子:
--
作者:
S. Ricksten;T. Yao;B. Ljung;P. Thoren
通讯作者:
P. Thoren
DOI:
10.1161/01.hyp.11.4.326
发表时间:
1988
期刊:
Hypertension (Dallas, Tex. : 1979)
影响因子:
--
作者:
Koepke,JP;Jones,S;DiBona,GF
通讯作者:
DiBona,GF
DOI:
--
发表时间:
1981
期刊:
Acta Physiologica Scandinavica
影响因子:
--
作者:
S. Ricksten;T. Yao;G. Di Bona;P. Thoren
通讯作者:
P. Thoren