Neuromodulatory processes of the brain-gut axis.
Neuromodulatory processes of the brain-gut axis.
复制标题
脑肠轴的神经调节过程。
DOI：
10.1111/j.1525-1403.2008.00172.x
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发表时间：
2008-10-01
期刊：
影响因子：
2.8
通讯作者：
Kuo, Braden
中科院分区：
文献类型：
--
作者：
Gaman, Alexandru;Kuo, Braden
Brain-gut axis represents a complex reflex circuit that integrates the communication between cortex and the digestive system. Disturbances of the neuromodulatory processes in the brain-gut axis generate functional digestive disorders mainly centered on the pain symptoms and motility disorders. This article reviews structural and patho-physiological aspects of the brain-gut axis and explains how the neuromodulatory interventions currently used in order to treat GI conditions related to the brain-gut axis disturbances. The neuromodulation can be realized by pharmacological targeting mainly receptors in the periphery or using electrical stimulation applied at different levels of the nervous system or directly in the muscular layers of the bowels resulting in modulation of the digestive system activity. The efficacy of the methods using electrostimulation is dependent on the parameters of the physical system used: amplitude, frequency, burst time of the electrical current and also the positioning of the electrodes. While pharmacological interventions are largely used at the moment, neuromodulatory interventions involving electrical stimulation showed clinical efficacy in research trials and have promise.
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通讯作者：
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Poitras, P
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Ischia, S