Central Circadian Clock Regulates Energy Metabolism.

Central Circadian Clock Regulates Energy Metabolism.
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DOI:
10.1007/978-981-13-1286-1_5
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发表时间:
2018
影响因子:
--
通讯作者:
Sun Z
Sun Z
中科院分区:
医学4区
文献类型:
--
作者:
Ding G;Gong Y;Eckel-Mahan KL;Sun Z

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我们的身体不仅能对环境变化做出反应,还能预见到环境的变化。光和暗周期约为24小时,是一种反复出现的环境变化,决定了自然界中捕食者对食物供应和安全的日变化。因此,在大多数动物中,生物钟的进化是为了使运动行为和能量代谢与光信号相一致。哺乳动物的中央生物钟位于大脑下丘脑的视交叉上核(SCN)。我们在此综述哺乳动物中心生物钟的分子和解剖结构;描述表明中心生物钟在塑造全身能量代谢中的关键作用的实验和观察证据;并讨论内分泌因子、神经肽和自主神经系统在中心生物钟的代谢功能中的参与。
Our body not only responds to environmental changes but also anticipates them. The light and dark cycle with the period of about 24 hours is a recurring environmental change that determines the diurnal variation in food availability and safety from predators in nature. As a result, the circadian clock is evolved in most animals to align locomotor behaviors and energy metabolism with the light cue. The central circadian clock in mammals is located at the suprachiasmatic nucleus (SCN) of the hypothalamus in the brain. We here review the molecular and anatomic architecture of the central circadian clock in mammals; describe the experimental and observational evidence that suggests a critical role of the central circadian clock in shaping systemic energy metabolism; and discuss the involvement of endocrine factors, neuropeptides, and the autonomic nervous system in the metabolic functions of the central circadian clock.
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