Serum copeptin levels in adolescents with primary hypertension.
Serum copeptin levels in adolescents with primary hypertension.
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DOI：
10.1007/s00467-013-2683-5
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发表时间：
2014-03
影响因子：
3
通讯作者：
Waszkiewicz-Stojda, Marlena
中科院分区：
文献类型：
--
作者：
Tenderenda-Banasiuk, Edyta;Wasilewska, Anna;Filonowicz, Renata;Jakubowska, Urszula;Waszkiewicz-Stojda, Marlena
高血压在儿科人群中的患病率继续上升。近年来，有关血清精氨酸加压素及其衍生物Copeptin控制血压的报道越来越多，但其作用尚不清楚。本研究的目的是评估青少年高血压患者的血清铜绿素水平。研究队列包括84名年龄在11-18岁的受试者(30名女孩和54名男孩)，分为两组：高血压组(HT)-53例确诊为原发性高血压者和R-参照组-31例在动态血压监测(ABPM)的基础上排除高血压(白大衣高血压)。使用市售的酶联免疫吸附分析试剂盒(USCN)测定血清铜绿素浓度。高血压组血清铜绿素水平(中位数，267[Q1~Q3：151.1~499.7 pg/ml])高于对照组(中位数107.3[Q1~Q3：36.7~203.4 pg/ml]，p <； 0.01)。男性和女性的差异均有统计学意义。在两组中，血清铜绿素水平与尿酸水平(r = 0.31，p <； 0.0 1)、蛋白尿(r = 0.45，p <； 0.0 1)、血清甘油三酯(r = 0.3，p <； 0.0 5)、体重指数标准差评分(r = 0.2 4，p <；SDS值)呈正相关。 0.0 5)和2 4h收缩压(r = 0.37，p <； 0.0 1)和舒张压(r = 0.2 3，p <； 0.0 5)。总而言之，较高的血清铜绿素水平，作为精氨酸加压素(AVP)释放的替代指标，不仅与收缩压和舒张压有关，还与代谢综合征的几个组成部分有关，包括肥胖、甘油三酯浓度升高、蛋白尿和血清尿酸水平。然而，就目前而言，还需要更多的研究来证实血清Copeptin作为高血压的新标记物和代谢综合征的预测因子的作用。
The prevalence of hypertension continues to rise in the pediatric population. In recent years, there has been an increasing amount of reports on serum arginine vasopressin and its derivative, copeptin, in blood pressure control, but its role is still unclear. The objective of this study was to assess serum copeptin in adolescents with essential hypertension. The study cohort consisted of 84 subjects (30 girls and 54 boys) aged 11–18 years, divided into two groups: hypertension (HT) – 53 subjects with confirmed primary hypertension and R - reference group – 31 subjects in whom hypertension was excluded on the basis of ambulatory blood pressure monitoring (ABPM) (white-coat hypertension). Serum copeptin concentration was measured using a commercially available enzyme-linked immunosorbent assay kit (USCN). Hypertensive patients had higher serum copeptin levels (median, 267 [Q1–Q3: 151.1–499.7 pg/ml]) than controls (median, 107.3 [Q1–Q3: 36.7–203.4 pg/ml]), (p < 0.01). Statistically significant difference was found both in males and females. In both groups, positive correlations between serum copeptin and uric acid levels (r = 0.31, p < 0.01), albuminuria (r = 0.45, p < 0.01), serum triglycerides (r = 0.3, p < 0.05), body mass index (BMI) standard deviation score (SDS) (r = 0.24, p < 0.05) and 24-h systolic blood pressure (SBP) (r = 0.37, p < 0.01) and diastolic blood pressure (DBP) (r = 0.23, p < 0.05) were found. In summary, higher serum copeptin levels, a surrogate for arginine vasopressin (AVP) release, are associated not only with systolic and diastolic blood pressure but also with several components of metabolic syndrome including obesity, elevated concentration of triglycerides, albuminuria, and serum uric acid level. However, for the time being, more research is needed in order to confirm the role of serum copeptin as a novel marker of elevated blood pressure and predictor of metabolic syndrome.
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DOI：
10.1111/j.1365-201x.2004.01333.x
发表时间：
2004-08-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
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作者：
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发表时间：
1979-01-01
期刊：
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DOI：
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发表时间：
2013-05-01
影响因子：
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作者：
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