Rising to the challenge of multiple Cryptococcus species and the diseases they cause.
Rising to the challenge of multiple Cryptococcus species and the diseases they cause.
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DOI：
10.1016/j.fgb.2015.05.002
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发表时间：
2015-05
影响因子：
3
通讯作者：
Lin, Xiaorong
中科院分区：
文献类型：
--
作者：
Idnurm, Alexander;Lin, Xiaorong
新生隐球菌和加蒂克雷氏菌是研究得很好的担子菌酵母，能够在健康和免疫功能低下的人中引起疾病。隐球菌和隐球菌病会议(ICCC)每三年举行一次：随附的特刊源于ICCC第九届会议，详细涵盖了与这些真菌相关的主题的一个子集。这次会议首先修订并降低了对全球疾病负担的估计，这在一定程度上是由于艾滋病毒+患者的治疗有所改善。然而，对于那些获得治疗机会有限或没有潜在免疫功能障碍的人来说，隐球菌病的死亡率一直很高。因此，在解决抗真菌药物的可获得性、新的抗真菌药物的必要性以及这些药物与抗病毒治疗相结合的时间和剂量方面仍有很长的路要走，这突显了继续研究的重要性。第九届ICCC会议的一个值得注意的问题是关于病原菌和寄主种群变异的研究。对隐球菌菌株变异性的分析，特别是在分子水平上的分析，已经解决了不同的谱系，这是分类修订的结果，将新生隐球菌和加蒂隐球菌分成7个隐球菌种。同样，对所谓的“免疫能力”个体的宿主因素的分析揭示了以前未被认识到的风险因素。对这些物种的研究使它们成为了解其他真菌和真核生物中基因进化和功能的重要模式生物。这一阶段是为了完善研究方向，最终导致更好地治疗这种隐球菌属的致病单系分支。
Cryptococcus neoformans and C. gattii are well-studied basidiomyceteous yeasts that are capable of causing disease in healthy and immunocompromised people. The Conference on Cryptococcus and Cryptococcosis (ICCC) is held every three years: the accompanying Special Issue stems from the 9th ICCC and covers a subset of the topics related to these fungi in detail. This conference started with a revised and reduced estimate of disease burden globally, in part due to improved treatment for HIV+ people. However, mortality from cryptococcosis remains consistently high for those unfortunate to have limited access to therapies or without underlying immunodefiencies. As such, there are yet still great distances to be covered to address antifungal drug availability, the need for new antifungal agents and the timing and doses of these agents in conjunction with antiviral therapy, underscoring the importance of continued research. A notable point from the 9th ICCC was the research addressing the variation in the pathogen and host populations. Analysis of cryptococcal strain variability, particularly at the molecular level, has resolved distinct lineages with the consequence of a taxonomic revision that divides C. neoformans and C. gattii into seven Cryptococcus species. Similarly, analysis of host factors in so called “immune-competent” individuals revealed previously unrecognized risk factors. Research on these species has established them as important model organisms to understand gene evolution and function in other fungi and eukaryotes. The stage is set for the refinement of research directions, leading ultimately to better treatment of this pathogenic monophyletic clade in the genus Cryptococcus.
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影响因子：
6.4
作者：
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通讯作者：
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DOI：
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发表时间：
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