Paediatric/congenital cardiology physician scientists-An endangered species.
Paediatric/congenital cardiology physician scientists-An endangered species.
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DOI：
10.1111/eci.13367
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发表时间：
2020-10
影响因子：
5.5
通讯作者：
Bezzerides V
中科院分区：
文献类型：
--
作者：
Hansmann G;Bezzerides V
培养优秀的医生科学家始于积极发现人才和奉献精神，并坚信医生参与生物医学研究对于改善人类健康的基本发现至关重要。结构性心脏病的外科和介入治疗的革命在过去几十年中对生存和生活质量产生了深远的积极影响。(...)在未来，临床改善的小增量仍然是可能的，但在大多数情况下，使用这些技术的重大进步的潜力已经耗尽“（Frank汉利，MD;斯坦福大学）。个性化医疗，快速遗传诊断，RNA和细胞外囊泡生物学，表观遗传学，基因编辑，基因和干细胞衍生治疗是典型的领域，儿科/先天性心脏病医生科学家的专业培训将越来越需要进一步推进该领域。大约十年前，《循环》杂志上的一系列文章讨论了学术职业模式，并强调了心血管“临床科学家”面临的主要挑战。科学家，从那以后就没有减少过。为了发展临床先天性心脏病和基础研究的技能和专业知识，研究员的培训必须集中和综合。当前的COVID-19大流行给旨在建立、巩固或扩大自己的研究团队的培训研究员（FIT）和早期职业研究员（ECI）带来了额外的压力和障碍。在这里，我们讨论了学术机构在未来几年维持和招募儿科/先天性心脏病医生科学家的主要挑战，机遇和必要的变化。
Producing excellent physician scientists starts with the active discovery of talent and dedication, supported by the strong belief that physician involvement in biomedical research is essential to make fundamental discoveries that improve human health. The revolution of surgical and interventional therapy of structural heart disease has had ‘profoundly positive effects on survival and quality of life over the decades. (…) Small increments in clinical improvement will still be possible in the future, but for the most part, the potential for major advancement using these techniques has been exhausted’ (Frank Hanley, MD; Stanford). Personalized medicine, rapid genetic diagnostics, RNA and extracellular vesicle biology, epigenetics, gene editing, gene and stem cell‐derived therapy are exemplary areas where specialized training for paediatric/congenital cardiology physician scientists will be increasingly needed to further advance the field. About a decade ago, a series in Circulation discussed academic career models and highlighted the major challenges facing the cardiovascular ‘clinician scientist’ (syn. physician scientist), which have not abated since. To develop the skills and expertise in both clinical congenital cardiology and basic research, the training of fellows must be focused and integrated. The current pandemic COVID‐19 puts additional pressure and hurdles on fellows‐in‐training (FIT) and early career investigators (ECI) who aim to establish, consolidate or expand their own research group. Here, we discuss the major challenges, opportunities and necessary changes for academic institutions to sustain and recruit physician scientists in paediatric/congenital cardiology in the years to come.
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影响因子：
1
作者：
Sallmon, Hannes;Moledina, Shahin;Hansmann, Georg
通讯作者：
Hansmann, Georg
影响因子：
168.9
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Bonhoeffer, P;Boudjemline, Y;Kachaner, J
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影响因子：
37.8
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Fuster, Valentin;van der Zee, Sarina;Bonow, Robert O.
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影响因子：
24
作者：
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Ross, Robert D.
影响因子：
5.4
作者：
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