Reduction of HPV infections through vaccination among at-risk urban adolescents.
Reduction of HPV infections through vaccination among at-risk urban adolescents.
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通过在高危城市青少年中接种疫苗来减少 HPV 感染。
DOI：
10.1016/j.vaccine.2012.06.057
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发表时间：
2012-08-10
期刊：
影响因子：
5.5
通讯作者：
Shew, Marcia L.
中科院分区：
文献类型：
--
作者：
Cummings, Teresa;Zimet, Gregory D.;Brown, Darron;Tu, Wanzhu;Yang, Ziyi;Fortenberry, J. Dennis;Shew, Marcia L.
人乳头瘤病毒(HPV)疫苗试验证明，在16-26岁的女性中预防HPV感染和HPV相关疾病具有很高的效果。然而，没有来源数据表明疫苗对其他可能有较高HPV相关疾病风险的人群的影响。这项研究考察了接种HPV疫苗对随后的HPV检测和临床环境下城市青少年的性行为的影响。一组14至17岁的青春期妇女被前瞻性地招募，并与历史对照相匹配，以评估HPV疫苗接种的影响。所有女性都完成了相同的问卷调查和面对面访谈，以评估性行为；所有女性都提供了临床医生或自行收集的阴道拭子，用于检测性传播感染，包括HPV。使用包含随机配对效应的Logistic回归模型来评估HPV疫苗对两组之间的HPV检测和性行为的影响。每个被招募的女性(N=75)与2个历史对照(HC)相匹配；大多数被招募的女性(89.3%)接种过一剂或多剂HPV疫苗。在登记时，招募组四价疫苗类型(HPV6、11、16和18)的检测率(5.3%)显著低于HC(24%)：OR=5.6(CI=1.9、16.5)，p=0.002。当分析调整为比较那些接种了2剂或更多疫苗的人与她们匹配的对照组时，HC中的青春期女性感染HPV的几率是对照组的9.5倍。唯一发现的行为差异是招募的女性更频繁地使用避孕套。这项研究表明，接种HPV疫苗与较少的疫苗类型HPV感染有关，尽管接种不完全和高危性行为。这些数据还表明，性行为并没有因为疫苗而改变。
Human papillomavirus (HPV) vaccine trials have demonstrated high efficacy in preventing HPV infections and HPV related disease in females ages 16–26. However, there is no source data to demonstrate the impact of the vaccine in other populations who may be at higher risk for HPV related disease. This study examines the impact of HPV vaccination on subsequent HPV detection and sexual behaviors among urban adolescents in a clinical setting. A cohort of adolescent women, ages 14 to 17, were recruited prospectively and matched to historical controls to assess the impact of HPV vaccination. All women completed the same questionnaire and face-to-face interview that assessed sexual behaviors; all provided a clinician or self-collected vaginal swab that was used to test for sexually transmitted infections, including HPV. Logistic regression models, incorporating random pair effects, were used to assess the impact of the HPV vaccine on HPV detection and sexual behaviors between the two groups. Each woman recruited (N=75) was matched to 2 historical controls (HC); most of the recruited women (89.3%) had received one or more doses of the HPV vaccine. At enrollment, detection of quadrivalent vaccine types (HPV 6, 11, 16 and 18) was significantly less in the recruited group (5.3%) as compared to the HC (24%): OR=5.6 (CI=1.9, 16.5), p=.002. Adolescent women in the HC had a 9.5 times greater odds of HPV infection when the analysis was adjusted to compare those who had 2 or more vaccine doses to their matched controls. The only behavioral difference found was that the recruited women used condoms more frequently. This study demonstrates that HPV vaccination was associated with fewer vaccine-type HPV infections despite incomplete vaccination and high risk sexual behaviors. These data also suggest that sexual behaviors were not altered because of the vaccine.
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DOI：
10.1111/j.1471-0528.2002.01053.x
发表时间：
2002-01-01
影响因子：
5.8
作者：
Collins, S;Mazloomzadeh, S;Woodman, CBJ
通讯作者：
Woodman, CBJ
影响因子：
--
作者：
Orr, DP;Johnston, K;Fortenberry, JD
通讯作者：
Fortenberry, JD
影响因子：
3.1
作者：
Ermel, A.;Qadadri, B.;Brown, D.
通讯作者：
Brown, D.
影响因子：
9.4
作者：
Gravitt, PE;Peyton, CL;Wheeler, CM
通讯作者：
Wheeler, CM
影响因子：
--
作者：
Mullins, Tanya L. Kowalczyk;Zimet, Gregory D.;Rosenthal, Susan L.;Morrow, Charlene;Ding, Lili;Shew, Marcia;Fortenberry, J. Dennis;Bernstein, David I.;Kahn, Jessica A.
通讯作者：
Kahn, Jessica A.