Functional imaging for prostate cancer: therapeutic implications.
Functional imaging for prostate cancer: therapeutic implications.
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DOI：
10.1053/j.semnuclmed.2012.04.004
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发表时间：
2012-09
影响因子：
4.9
通讯作者：
Seo Y
中科院分区：
文献类型：
--
作者：
Mari Aparici C;Seo Y
功能性放射性核素成像模式现在通常与解剖成像模式CT或MRI（SPECT/CT、PET/CT和PET/MRI）相结合，是治疗前列腺癌的有前途的工具，特别是具有治疗意义。使用这些成像方式的前列腺癌的灵敏检测能力是一个问题;然而，使用可以从功能性放射性核素成像技术获得的信息来治疗前列腺癌是另一个具有挑战性的领域。没有多少SPECT或PET放射性示踪剂可以覆盖前列腺癌管理的全部范围，从初始检测到分期，预后预测，一直到治疗反应评估。然而，如果使用得当，来自功能性放射性核素成像的信息可以改善，有时可以显著改变癌症管理的整个过程。使用SPECT和PET放射性示踪剂在治疗意义方面的局限性与其仅用于检测前列腺癌的局限性没有太大不同;然而，特定的成像靶点以及如何通过SPECT和PET可靠地成像该靶点可能对前列腺癌的治疗产生重大影响。最后，虽然局限性前列腺癌被认为是可管理的，但仍然需要改进转移性前列腺癌的非侵入性成像、治疗指导和功能成像（包括基于放射性核素的技术）的反应评估。在这篇综述文章中，我们提出了使用功能性放射性核素显像的基本原理和治疗意义的放射性核素显像剂，已在人类受试者的研究。
Functional radionuclide imaging modalities, now commonly combined with anatomical imaging modalities CT or MRI (SPECT/CT, PET/CT, and PET/MRI) are promising tools for the management of prostate cancer particularly for therapeutic implications. Sensitive detection capability of prostate cancer using these imaging modalities is one issue; however, the treatment of prostate cancer using the information that can be obtained from functional radionuclide imaging techniques is another challenging area. There are not many SPECT or PET radiotracers that can cover the full spectrum of the management of prostate cancer from initial detection, to staging, prognosis predictor, and all the way to treatment response assessment. However, when used appropriately, the information from functional radionuclide imaging improves, and sometimes significantly changes, the whole course of the cancer management. The limitations of using SPECT and PET radiotracers with regards to therapeutic implications are not so much different from their limitations solely for the task of detecting prostate cancer; however, the specific imaging target and how this target is reliably imaged by SPECT and PET can potentially make significant impact in the treatment of prostate cancer. Finally, while the localized prostate cancer is considered manageable, there is still significant need for improvement in noninvasive imaging of metastatic prostate cancer, in treatment guidance, and in response assessment from functional imaging including radionuclide-based techniques. In this review article, we present the rationale of using functional radionuclide imaging and the therapeutic implications for each of radionuclide imaging agent that have been studied in human subjects.
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影响因子：
7.3
作者：
Banerjee SR;Pullambhatla M;Byun Y;Nimmagadda S;Green G;Fox JJ;Horti A;Mease RC;Pomper MG
通讯作者：
Pomper MG
DOI：
10.1007/s00259-007-0516-0
发表时间：
2008-01-01
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.2967/jnumed.109.066159
发表时间：
2010-02
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
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通讯作者：
Humm JL
影响因子：
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作者：
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通讯作者：
Goldsmith, SJ