Characterization of T lymphocyte responses during primary infection with human immunodeficiency virus.
Characterization of T lymphocyte responses during primary infection with human immunodeficiency virus.
复制标题
人类免疫缺陷病毒初次感染期间 T 淋巴细胞反应的特征。
DOI：
10.1093/infdis/157.5.889
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
R. Penny
中科院分区：
文献类型：
--
作者：
D. Cooper;B. Tindall;E. Wilson;A. Imrie;R. Penny
本研究旨在确定T细胞对原发性人类免疫缺陷病毒（HIV）感染的反应。T细胞亚群无显着差异，发现受试者谁后来血清转换和一组对照。6名受试者在血清转换时进行了多次T细胞亚群计数。最初，总淋巴细胞和T细胞亚群计数减少。随后发现由于CD 8+细胞水平升高导致CD 4+：CD 8+比率倒置，随后CD 8+细胞数量明显增加，CD 4+：CD 8+比率进一步倒置。最后，CD 8+细胞计数恢复正常，但仍高于CD 4+细胞计数;保持倒置比例。淋巴细胞对有丝分裂原和抗原的低反应性被发现在血清转换疾病的一个主题。在有数据的5名受试者中，3名受试者的CD 8+细胞绝对数量增加，随后血清HIV抗原水平下降。
The present study was undertaken to determine T cell response to primary human immunodeficiency virus (HIV) infection. No significant difference in T cell subsets was found between subjects who later seroconverted and a group of controls. Six subjects had multiple enumerations of T cell subsets done at the time of seroconversion. Initially, total lymphocyte and T cell subset counts were reduced. An inversion of the CD4+:CD8+ ratio due to a rise in the level of CD8+ cells was found later, followed by an appreciable increase in the number of CD8+ cells and further inversion of the CD4+:CD8+ ratio. Finally, the CD8+ cell count returned toward normal but remained higher than the CD4+ cell count; the inverted ratio was maintained. Lymphocyte hyporesponsiveness to mitogens and antigens was found during the seroconversion illness in one subject. In three of five subjects for whom data were available, an increase in the absolute number of CD8+ cells followed a decrease in the serum HIV antigen level.
巨细胞病毒单核细胞增多症中 T 淋巴细胞亚群的分析。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Carney,WP;Rubin,RH;Hoffman,RA;Hansen,WP;Healey,K;Hirsch,MS
通讯作者：
Hirsch,MS
影响因子：
39.2
作者：
MORRIS, L;DISTENFELD, A;KARPATKIN, S
通讯作者：
KARPATKIN, S