Changing mortality profile among HIV-infected patients in Rio de Janeiro, Brazil: shifting from AIDS to non-AIDS related conditions in the HAART era.
Changing mortality profile among HIV-infected patients in Rio de Janeiro, Brazil: shifting from AIDS to non-AIDS related conditions in the HAART era.
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DOI：
10.1371/journal.pone.0059768
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Veloso VG
中科院分区：
文献类型：
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作者：
Grinsztejn B;Luz PM;Pacheco AG;Santos DV;Velasque L;Moreira RI;Guimarães MR;Nunes EP;Lemos AS;Ribeiro SR;Campos DP;Vitoria MA;Veloso VG
我们描述了奥斯瓦尔多·克鲁兹基金会(Fiocruz)Evandro Chagas临床研究所(IPEC)的死亡率以及与艾滋病和非艾滋病相关死亡相关因素的时间趋势。从1986年到2009年登记的成年患者至少随访60天。使用患者的病历，通过与个人和家庭成员的积极接触，并使用先前验证的算法与里约热内卢死亡率数据库建立联系，对生命状况进行了详尽的检查。代码协议被用来确定死因。多变量建模采用扩展的COX比例风险模型。共有3530人符合纳入标准，其中868人(24.6%)死亡；每个患者的平均随访时间为3.9年(四分位数范围为1.7-9.2年)。总死亡率的大幅下降是由与艾滋病有关的原因推动的，从1986-1991年的9.19/100PYs下降到2007-2009年的1.35/100PYs。非艾滋病相关死亡率在一段时间内保持稳定，约为1/100PYs。免疫缺陷显著增加了艾滋病相关和非艾滋病相关死亡原因的风险，而HAART的使用与这两种原因的死亡风险降低密切相关。我们的结果证实，随着艾滋病毒流行的演变，与艾滋病相关的死亡率显著下降，并对传统上与艾滋病毒/艾滋病无关的疾病发出警报，这些疾病现在变得更加频繁，需要仔细监测。
We describe temporal trends in the mortality rates and factors associated with AIDS and non-AIDS related mortality at the Evandro Chagas Clinical Research Institute (IPEC), Oswaldo Cruz Foundation (FIOCRUZ). Adult patients enrolling from 1986 through 2009 with a minimum follow up of 60 days were included. Vital status was exhaustively checked using patients’ medical charts, through active contact with individuals and family members and by linkage with the Rio de Janeiro Mortality database using a previously validated algorithm. The CoDe protocol was used to establish the cause of death. Extended Cox proportional hazards models were used for multivariate modeling. A total of 3530 individuals met the inclusion criteria, out of which 868 (24.6%) deceased; median follow up per patient was 3.9 years (interquartile range 1.7–9.2 years). The dramatic decrease in the overall mortality rates was driven by AIDS-related causes that decreased from 9.19 deaths/100PYs n 1986–1991 to 1.35/100PYs in 2007–2009. Non-AIDS related mortality rates remained stable overtime, at around 1 death/100PYs. Immunodeficiency significantly increased the hazard of both AIDS-related and non-AIDS-related causes of death, while HAART use was strongly associated with a lower hazard of death from either cause. Our results confirm the remarkable decrease in AIDS-related mortality as the HIV epidemic evolved and alerts to the conditions not traditionally related to HIV/AIDS which are now becoming more frequent, needing careful monitoring.
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HAART启动和人类免疫缺陷病毒1型血清抗体的时机。
影响因子：
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作者：
Funk, Michele Jonsson;Fusco, Jennifer S.;Cole, Stephen R.;Thomas, James C.;Porter, Kholoud;Kaufman, Jay S.;Davidian, Marie;White, Alice D.;Hartmann, Katherine E.;Eron, Joseph J., Jr.
通讯作者：
Eron, Joseph J., Jr.
影响因子：
3.8
作者：
Martinson, Neil A.;Karstaedt, Alan;Hale, Martin
通讯作者：
Hale, Martin
影响因子：
3.8
作者：
Grinsztejn, Beatriz;Veloso, Valdilea G.;Moore, Richard D.
通讯作者：
Moore, Richard D.
DOI：
10.1590/s1413-81232004000400011
发表时间：
2004-12-01
期刊：
Ciência & Saúde Coletiva
影响因子：
--
作者：
Schramm, Joyce Mendes de Andrade;Oliveira, Andreia Ferreira de;Campos, Mônica Rodrigues
通讯作者：
Campos, Mônica Rodrigues
影响因子：
11.8
作者：
Lichtenstein, Kenneth A.;Armon, Carl;Brooks, John T.
通讯作者：
Brooks, John T.