Reduced motion external defibrillation: Reduced subject motion with equivalent defibrillation efficiency validated in swine.
Reduced motion external defibrillation: Reduced subject motion with equivalent defibrillation efficiency validated in swine.
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减少运动的体外除颤：减少受试者的运动，在猪身上验证同等的除颤效率。
DOI：
10.1016/j.hrthm.2022.02.021
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发表时间：
2022-07
期刊：
影响因子：
5.5
通讯作者：
Halperin, Henry R.
中科院分区：
文献类型：
--
作者：
Schmidt, Ehud J.;Elahi, Hassan;Meyer, Eric S.;Baumgaertner, Ryan;Neri, Luca;Berger, Ronald D.;Tandri, Harikrishna;Hunter, David W.;Cohen, Steven P.;Oberdier, Matt T.;Halperin, Henry R.
关键词：
体外除颤器用于心律失常复律和心脏骤停期间的除颤器。在除颤过程中，由于胸壁肌肉快速收缩，短时间双相脉冲引起剧烈运动。将商用除颤器与强直波形发生器相结合，构建了一种减动式体外除颤器（RMD）。在双相脉冲之前，长时间的低振幅破伤风波形缓慢刺激胸部肌肉，减少休克期间的肌肉收缩。评估猪RMD除颤在除颤脉冲期间的主体运动和除颤有效性。RMD除颤可以缩短心律失常消融治疗的持续时间或简化心律转复程序。破伤风装置发出一个三角形的1 khz脉冲，持续时间为0.25 - 2.0秒，峰值振幅为10 - 100伏，随后触发传统的除颤器在下一个r波输出标准的1-200J能量双相脉冲。通过测量RMD（破伤风+双相）或双相脉冲波形中10−3秒采样率下的峰值加速度和肢体功来评估肢体前运动。7头猪被电击并随后去纤颤。单双相脉冲除颤器和RMD除颤器每头猪重复25-35次，不同的破伤风参数和双相脉冲能量。除颤阈值（DFTs）是通过测量仅双相脉冲或RMD除颤恢复窦性心律所需的最小能量来确定的。强直波形和双相脉冲均出现两个前肢加速峰，表明痛觉（痛觉）神经纤维激活快速和缓慢。与仅双相脉冲除颤器相比，最佳RMD破伤风参数（25-35V, 0.25 - 0.75秒持续时间）可使峰值加速度减小74±10%，肢体工作减少85±10%。DFT能量是相同的，比较RMD和双相脉冲除颤器。与传统的除颤器相比，RMD除颤器在大幅度减少受试者运动的情况下保持心律恢复效率。
External defibrillators are used for arrhythmia cardioversion and for defibrillating during cardiac arrest. During defibrillation, short-duration Biphasic pulses cause intense motion due to rapid chest-wall muscle contraction. A reduced-motion external defibrillator (RMD) was constructed by integrating a commercial defibrillator with a Tetanizing-waveform generator. A long-duration low-amplitude Tetanizing-waveform slowly stimulated the chest musculature prior to the Biphasic pulse, reducing muscle contraction during the shock. Evaluate RMD defibrillation in swine for subject-motion during defibrillation pulses and for defibrillation effectiveness. RMD defibrillation can reduce the duration of arrhythmia ablation-therapy or simplify cardioversion procedures. The Tetanizing unit delivered a triangular 1-kHz pulse of 0.25–2.0sec duration and 10–100Volt peak amplitude, subsequently triggering the conventional defibrillator to output standard 1–200J energy Biphasic pulses at the next R-wave. Forward-limb motion was evaluated by measuring Peak Acceleration and Limb Work during RMD (Tetanizing+Biphasic) or Biphasic-pulse-only waveforms at 10−3sec sampling-rate. Seven swine were arrested electrically and subsequently defibrillated. Biphasic-pulse-only and RMD defibrillations were repeated 25–35 times/swine, varying Tetanizing parameters and the Biphasic-pulse energy. Defibrillation thresholds (DFTs) were established by measuring the minimum energy required to restore sinus-rhythm with Biphasic-pulse-only or RMD defibrillations. Two forward-limb acceleration-peaks occurred during both the Tetanizing-waveform and Biphasic-pulse, indicating rapid and slower nociceptic (pain-sensation) nerve-fiber activation. Optimal RMD Tetanizing-parameters (25–35V, 0.25–0.75sec duration), relative to Biphasic-pulse-only defibrillations, resulted in 74±10% smaller Peak Accelerations and 85±10% reduced Limb Work. DFT energies were identical, comparing RMD to Biphasic-pulse-only defibrillations. Relative to conventional defibrillations, RMD defibrillations maintain rhythm-restoration efficiency with drastically reduced subject-motion.
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磁共振成像条件外部心脏除颤器，用于在磁共振成像扫描仪孔内复苏。
DOI：
10.1161/circimaging.116.005091
发表时间：
2016-10
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Schmidt EJ;Watkins RD;Zviman MM;Guttman MA;Wang W;Halperin HA
通讯作者：
Halperin HA
影响因子：
3.7
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影响因子：
6.1
作者：
de Ridder, Stijn;Timmermans, Carl;Wellens, Hein J. J.
通讯作者：
Wellens, Hein J. J.
影响因子：
8.4
作者：
Ranjan, Ravi;Kato, Ritsushi;Halperin, Henry R.
通讯作者：
Halperin, Henry R.
影响因子：
2.7
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Morton DL;Sandhu JS;Jones AK
通讯作者：
Jones AK