Genome-Wide Association Studies and Runs of Homozygosity to Identify Reproduction-Related Genes in Yorkshire Pig Population.
Genome-Wide Association Studies and Runs of Homozygosity to Identify Reproduction-Related Genes in Yorkshire Pig Population.
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繁殖性状在生猪育种和生产中具有相当大的经济重要性。然而，支撑生殖性状的候选基因仍然知之甚少。在本研究中，我们使用 PorcineSNP50 BeadChip 芯片对 585 头约克夏猪进行了全基因组关联研究 (GWAS) 和纯合性 (ROH) 分析。 GWAS 的结果确定了与七种生殖性状相关的两个全基因组显着性和十八个暗示性显着单核苷酸多态性 (SNP)。此外，我们还确定了候选基因，包括 ELMO1、AOAH、INSIG2、NUP205、LYPLAL1、RPL34、LIPH、RNF7、GRK7、ETV5、FYN 和 SLC30A5，之所以选择这些基因是因为相邻的显着 SNP 及其在免疫、受精、胚胎发育和精子质量方面的功能。在 ROH 岛中发现了与精子、胎儿发育、成熟卵子和窝产仔数相关的多个基因，包括 INSL6、TAF4B、E2F7、RTL1、CDKN1C 和 GDF9。这项研究将深入了解猪繁殖性状的遗传基础，利用基于标记的选择方法促进繁殖改良。
Reproductive traits hold considerable economic importance in pig breeding and production. However, candidate genes underpinning the reproductive traits are still poorly identified. In the present study, we executed a genome-wide association study (GWAS) and runs of homozygosity (ROH) analysis using the PorcineSNP50 BeadChip array for 585 Yorkshire pigs. Results from the GWAS identified two genome-wide significant and eighteen suggestive significant single nucleotide polymorphisms (SNPs) associated with seven reproductive traits. Furthermore, we identified candidate genes, including ELMO1, AOAH, INSIG2, NUP205, LYPLAL1, RPL34, LIPH, RNF7, GRK7, ETV5, FYN, and SLC30A5, which were chosen due to adjoining significant SNPs and their functions in immunity, fertilization, embryonic development, and sperm quality. Several genes were found in ROH islands associated with spermatozoa, development of the fetus, mature eggs, and litter size, including INSL6, TAF4B, E2F7, RTL1, CDKN1C, and GDF9. This study will provide insight into the genetic basis for pig reproductive traits, facilitating reproduction improvement using the marker-based selection methods.
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测序数据揭示莱芜猪纯合性的全基因组检测
影响因子：
3.7
作者：
Fang Y;Hao X;Xu Z;Sun H;Zhao Q;Cao R;Zhang Z;Ma P;Sun Y;Qi Z;Wei Q;Wang Q;Pan Y
通讯作者：
Pan Y
影响因子：
5.2
作者：
Lovasco, Lindsay A.;Gustafson, Eric A.;Seymour, Kimberly A.;de Rooij, Dirk G.;Freiman, Richard N.
通讯作者：
Freiman, Richard N.
影响因子：
3.7
作者：
Jamsai D;Clark BJ;Smith SJ;Whittle B;Goodnow CC;Ormandy CJ;O'Bryan MK
通讯作者：
O'Bryan MK
DOI：
10.1016/j.bbrc.2006.03.208
发表时间：
2006-06-09
影响因子：
3.1
作者：
Cao, Qinhong;Chen, Jie;Li, Jianmin
通讯作者：
Li, Jianmin
影响因子：
6.7
作者：
Bellver, Jose;Pellicer, Antonio;Meseguer, Marcos
通讯作者：
Meseguer, Marcos