Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation.
Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation.
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DOI：
10.3390/ma13204619
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发表时间：
2020-10-16
期刊：
影响因子：
--
通讯作者：
Dall'Ara E
中科院分区：
文献类型：
--
作者：
Ryan MK;Oliviero S;Costa MC;Wilkinson JM;Dall'Ara E
骨关节炎（OA）是一种慢性疾病，影响大约三分之一的45岁以上人群。虽然疾病的病因和发病机制尚不清楚，但力学在骨关节炎的发生和发展中都起着重要作用。在这项研究中，我们展示了逐步压缩的应用，结合微ct成像和数字体积相关（DVC）来测量和评估骨关节炎股骨头在单轴压缩下的全场应变分布。综合分析表明OA骨固有的显微结构特征并不影响与应用方法相关的不确定性水平。结果表明应变在加载表面以及低骨体积分数和软骨下囊肿区域的局部化。骨小梁厚度和连通性密度被认为是与表观屈服应变测量的局部应变大小或超过屈服应变的骨体积有任何关联的唯一微观结构参数。这项工作展示了一种评估严重骨关节炎患者整个人类股骨头力学特性的新方法。
Osteoarthritis (OA) is a chronic disease, affecting approximately one third of people over the age of 45. Whilst the etiology and pathogenesis of the disease are still not well understood, mechanics play an important role in both the initiation and progression of osteoarthritis. In this study, we demonstrate the application of stepwise compression, combined with microCT imaging and digital volume correlation (DVC) to measure and evaluate full-field strain distributions within osteoarthritic femoral heads under uniaxial compression. A comprehensive analysis showed that the microstructural features inherent in OA bone did not affect the level of uncertainties associated with the applied methods. The results illustrate the localization of strains at the loading surface as well as in areas of low bone volume fraction and subchondral cysts. Trabecular thickness and connectivity density were identified as the only microstructural parameters with any association to the magnitude of local strain measured at apparent yield strain or the volume of bone exceeding yield strain. This work demonstrates a novel approach to evaluating the mechanical properties of the whole human femoral head in case of severe OA.
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影响因子：
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作者：
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