SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission.
SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission.
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DOI：
10.1016/j.coviro.2011.10.012
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发表时间：
2011-12
影响因子：
5.9
通讯作者：
Baric, Ralph
中科院分区：
文献类型：
--
作者：
Bolles, Meagan;Donaldson, Eric;Baric, Ralph
冠状病毒通过不同的分子机制维持多样性的遗传。蝙蝠冠状病毒的遗传学和受体的使用可能表明SARS-CoV的直接出现。SARS刺突受体结合是跨物种传播的最小决定因素。突变和重组驱动的变化，以刺突驱动CoV宿主范围扩大。新的结构建模工具允许评估受体结合决定簇。大多数新出现的病毒来自人畜共患病宿主中流行的毒株。冠状病毒在驯养动物中具有跨物种传播的潜力，但在2002年突然与人畜共患病宿主中意外出现的高致病性人SARS冠状病毒株有关。在公共卫生措施阻止疫情之前，SARS-CoV感染了全球约8000人。在强有力的时间顺序序列变异、结构生物学、充分表征的患者库和生物学数据的支持下，SARS-CoV的出现代表了从人畜共患病来源中出现病毒性疾病的最佳研究自然模型之一。这篇综述文章总结了以前和最近的分子和结构特征的进展，特别强调宿主-受体相互作用，推动了这一显着的病毒疾病在人群中爆发。
► Coronaviruses maintain a diverse phylogeny by distinct molecular mechanisms. ► BatCoV phylogenetics and receptor use may suggest a direct emergence of SARS-CoV. ► SARS Spike–receptor binding is the minimum determinant of cross-species transmission. ► Mutation and recombination-driven changes to Spike drive CoV host range expansion. ► Novel structural modeling tools allow assessment of receptor-binding determinants. Most new emerging viruses are derived from strains circulating in zoonotic reservoirs. Coronaviruses, which had an established potential for cross-species transmission within domesticated animals, suddenly became relevant with the unexpected emergence of the highly pathogenic human SARS-CoV strain from zoonotic reservoirs in 2002. SARS-CoV infected approximately 8000 people worldwide before public health measures halted the epidemic. Supported by robust time-ordered sequence variation, structural biology, well-characterized patient pools, and biological data, the emergence of SARS-CoV represents one of the best-studied natural models of viral disease emergence from zoonotic sources. This review article summarizes previous and more recent advances into the molecular and structural characteristics, with particular emphasis on host–receptor interactions, that drove this remarkable virus disease outbreak in human populations.
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DOI：
10.1016/j.ijantimicag.2010.06.016
发表时间：
2010-11
影响因子：
10.8
作者：
Anderson LJ;Tong S
通讯作者：
Tong S
影响因子：
11.4
作者：
Li, WH;Zhang, CS;Sui, JH;Kuhn, JH;Moore, MJ;Luo, SW;Wong, SK;Huang, IC;Xu, KM;Vasilieva, N;Murakami, A;He, YQ;Marasco, WA;Guan, Y;Choe, HY;Farzan, M
通讯作者：
Farzan, M
影响因子：
5.4
作者：
Bosch, Berend Jan;Bartelink, Willem;Rottier, Peter J. M.
通讯作者：
Rottier, Peter J. M.
影响因子：
5.4
作者：
Glowacka, Ilona;Bertram, Stephanie;Poehlmann, Stefan
通讯作者：
Poehlmann, Stefan
影响因子：
3.6
作者：
Janies, Daniel;Habib, Farhat;Pol, Diego
通讯作者：
Pol, Diego