Evidence of proatherogenic inflammation in polycystic ovary syndrome.
Evidence of proatherogenic inflammation in polycystic ovary syndrome.
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DOI：
10.1016/j.metabol.2009.02.022
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发表时间：
2009-07
影响因子：
9.8
通讯作者：
Kirwan, John P.
中科院分区：
文献类型：
--
作者：
Gonzalez, Frank;Rote, Neal S.;Minium, Judi;Kirwan, John P.
患有多囊卵巢综合征(PCOS)的女性有慢性低水平炎症，这会增加动脉粥样硬化的风险。我们测定了PCOS患者(8例瘦体重指数，18-25 kg/m2，8例肥胖体重指数，30-40 kg/m2)和体重匹配的对照组(8例瘦体重，8例肥胖)的循环促动脉粥样硬化炎症介质。空腹及餐后2小时采血检测单个核细胞中白细胞介素6、可溶性细胞间黏附分子1、单核细胞趋化蛋白1、C反应蛋白、基质金属蛋白酶2、纤溶酶原激活物抑制物1、活化核因子κB(NFκB)水平。用DEXA测定躯干脂肪含量。患有多囊卵巢综合征的瘦身女性空腹MCP-1水平高于瘦身对照组(159.9±14.1pg/ml对121.2±5.4pg/ml，p<；0.02)。与瘦身对照组相比，高血糖未能抑制多囊卵巢综合征患者的基质金属蛋白酶-2(1.7±1.2vs.−4.8±1.6pg/ml，p<；0.002)。在患有多囊卵巢综合征的女性中，肥胖患者的空腹sICAM-1(16.1±0.8vs.10.5±1.0 ng/mlp<；0.03)和PAI-1(6.1±0.7vs.3.4±0.8 ng/mlp<；0.03)水平较高。趋势分析显示，与体重匹配的对照组相比，多囊卵巢综合征患者的(p<；0.005)IL-6、sICAM-1、C反应蛋白和纤溶酶原激活物-1、收缩压和舒张压、甘油三酯、空腹胰岛素和HOMA-IR水平更高，肥胖者的水平最高，与多囊卵巢综合征的状况无关。在高血糖(p<；0.004)和雄烯二酮(p<；0.004)期间，空腹mcp-1水平与激活的核因子κB相关。躯干脂肪与空腹IL-6(p<；0.004)、sICAM-1(p<；0.006)、C反应蛋白(p<；0.0009)和纤溶酶原激活物-1(p<；0.02)相关。我们得出结论，多囊卵巢综合征和肥胖都会导致动脉粥样硬化，但在患有多囊卵巢综合征的女性中，腹部肥胖和高雄激素血症可能会加剧动脉粥样硬化的风险。
Women with Polycystic Ovary Syndrome (PCOS) have chronic low level inflammation which can increase the risk of atherogenesis. We measured circulating proatherogenic inflammatory mediators in women with PCOS (8 lean - BMI, 18–25 kg/m2, 8 obese -BMI, 30–40 kg/m2) and weight-matched controls (8 lean, 8 obese). Blood samples were obtained fasting and 2 hours after glucose ingestion to measure interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), monocyte chemotactic protein-1 (MCP-1), C-reactive protein (CRP), matrix metalloproteinase-2 (MMP-2), plasminogen activator inhibitor-1 (PAI-1), and activated nuclear factor κB (NFκB) in mononuclear cells. Truncal fat was determined by DEXA. Fasting MCP-1 levels were elevated in lean women with PCOS compared to lean controls (159.9±14.1 vs. 121.2±5.4 pg/ml, p<0.02). Hyperglycemia failed to suppress MMP-2 in lean women with PCOS compared to lean controls (1.7±1.2 vs. −4.8±1.6 pg/ml, p<0.002). Among women with PCOS, obese individuals exhibited higher fasting sICAM-1 (16.1±0.8 vs. 10.5±1.0 ng/ml, p<0.03) and PAI-1 (6.1±0.7 vs. 3.4±0.8 ng/ml, p<0.03) levels. Trend analysis revealed higher (p<0.005) IL-6, sICAM-1, CRP and PAI-1, systolic and diastolic blood pressures, triglycerides, fasting insulin and HOMA-IR in women with PCOS compared to weight-matched controls, and the highest levels in the obese regardless of PCOS status. Fasting MCP-1 levels correlated with activated NFκB during hyperglycemia (p<0.05) and androstendione (p<0.004). Truncal fat correlated with fasting IL-6 (p<0.004), sICAM-1 (p<0.006), CRP (p<0.0009) and PAI-1 (p<0.02). We conclude that both PCOS and obesity contribute to a proatherogenic state, but in women with PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherosclerosis.
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