The Structural Diversity of Marine Microbial Secondary Metabolites Based on Co-Culture Strategy: 2009-2019.
The Structural Diversity of Marine Microbial Secondary Metabolites Based on Co-Culture Strategy: 2009-2019.
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DOI：
10.3390/md18090449
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发表时间：
2020-08-27
期刊：
影响因子：
5.4
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Chen J;Zhang P;Ye X;Wei B;Emam M;Zhang H;Wang H
海洋微生物作为一种新型的生物活性天然产物资源，特别是在药物开发领域，已引起人们的广泛关注。使用不同的策略，海洋微生物有能力产生各种各样的分子。这些策略之一是海洋微生物的共培养;如果两种或多种微生物在一定环境中在固体或液体培养基中无菌培养在一起，它们的竞争或协同关系可以激活沉默的生物合成基因，以产生在伴侣微生物的单一培养物中不存在的隐藏的天然产物。近年来，海洋微生物共培养策略使更多具有多种生物活性的新型天然产物产生。本文综述了2009 - 2019年基于海洋微生物共培养的次级代谢产物的来源、类型、结构和生物活性。并对未来的发展前景和面临的挑战进行了详细的讨论，提出了作者对未来发展趋势的看法。
Marine microorganisms have drawn great attention as novel bioactive natural product sources, particularly in the drug discovery area. Using different strategies, marine microbes have the ability to produce a wide variety of molecules. One of these strategies is the co-culturing of marine microbes; if two or more microorganisms are aseptically cultured together in a solid or liquid medium in a certain environment, their competition or synergetic relationship can activate the silent biosynthetic genes to produce cryptic natural products which do not exist in monocultures of the partner microbes. In recent years, the co-cultivation strategy of marine microbes has made more novel natural products with various biological activities. This review focuses on the significant and excellent examples covering sources, types, structures and bioactivities of secondary metabolites based on co-cultures of marine-derived microorganisms from 2009 to 2019. A detailed discussion on future prospects and current challenges in the field of co-culture is also provided on behalf of the authors’ own views of development tendencies.
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影响因子：
0.8
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Bugni TS
DOI：
10.1073/pnas.1433065100
发表时间：
2003-07-22
影响因子：
11.1
作者：
Dey, A;Chitsaz, F;Ozato, K
通讯作者：
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