An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 2: Overall Variabilities in Absorbed Dose.
An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 2: Overall Variabilities in Absorbed Dose.
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DOI：
10.2967/jnumed.122.265094
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发表时间：
2023-07
影响因子：
9.3
通讯作者：
Uribe, Carlos
中科院分区：
文献类型：
--
作者：
Brosch-Lenz, Julia;Ke, Suqi;Wang, Hao;Frey, Eric;Dewaraja, Yuni K.;Sunderland, John;Uribe, Carlos
个体化放射性药物治疗的剂量测定已经获得了相当大的关注。已经开发了许多方法、工具和工作流程来估计吸收剂量（AD）。然而，仍然需要标准化来减少各中心AD估计值的变异性。标准化的一项努力是核医学和分子成像学会177 Lu剂量测定挑战，其包括5项任务（T1-T5），旨在评估与剂量测定工作流程的成像协议（T1与T2与T3）、分割（T1与T4）、时间积分（T4与T5）和剂量计算（T5）步骤相关的剂量估计变异性。这项工作的目的是评估不同任务的AD计算的总体变异性。研究方法：分析数据集包括连续平面和定量SPECT/CT扫描、器官和病变轮廓以及2例接受177 Lu-DOTATATE治疗的患者的时间积分活动图，供参与者在全球范围内进行剂量计算并在标准化提交电子表格中提交结果。这些数据经过精心整理，以避免形式错误和方法错误。计算AD的一般描述性统计量，并进行统计分析以比较不同任务的结果。使用四分位离散系数测量AD的变异性。结果如下：平面成像方案（T2）估计的器官AD比单纯SPECT/CT（T1）估计的器官AD低约60%，差异有统计学意义。重要的是，当至少有1次SPECT/CT采集可用时（T1、T3、T4、T5），剂量估计值的平均差异在± 10%范围内，对于大多数器官和病变，与T1的差异无统计学显著性。当使用连续SPECT/CT图像时，T1器官和病变的AD离散度的四分位系数平均分别小于20%和26%; T4分别为20%和18%（提供分割）; T5分别为10%和5%（提供分割和时间积分活动图像）。结论：AD的变异性降低了分割和时间积分数据提供给参与者。我们的研究结果表明，SPECT/CT为基础的成像协议比平面成像方法产生更一致和更少的变量结果。应努力使分割和拟合标准化，因为这可能会大大减少AD的变异性。
Dosimetry for personalized radiopharmaceutical therapy has gained considerable attention. Many methods, tools, and workflows have been developed to estimate absorbed dose (AD). However, standardization is still required to reduce variability of AD estimates across centers. One effort for standardization is the Society of Nuclear Medicine and Molecular Imaging 177Lu Dosimetry Challenge, which comprised 5 tasks (T1–T5) designed to assess dose estimate variability associated with the imaging protocol (T1 vs. T2 vs. T3), segmentation (T1 vs. T4), time integration (T4 vs. T5), and dose calculation (T5) steps of the dosimetry workflow. The aim of this work was to assess the overall variability in AD calculations for the different tasks. Methods: Anonymized datasets consisting of serial planar and quantitative SPECT/CT scans, organ and lesion contours, and time-integrated activity maps of 2 patients treated with 177Lu-DOTATATE were made available globally for participants to perform dosimetry calculations and submit their results in standardized submission spreadsheets. The data were carefully curated for formal mistakes and methodologic errors. General descriptive statistics for ADs were calculated, and statistical analysis was performed to compare the results of different tasks. Variability in ADs was measured using the quartile coefficient of dispersion. Results: ADs to organs estimated from planar imaging protocols (T2) were lower by about 60% than those from pure SPECT/CT (T1), and the differences were statistically significant. Importantly, the average differences in dose estimates when at least 1 SPECT/CT acquisition was available (T1, T3, T4, T5) were within ±10%, and the differences with respect to T1 were not statistically significant for most organs and lesions. When serial SPECT/CT images were used, the quartile coefficients of dispersion of ADs for organs and lesions were on average less than 20% and 26%, respectively, for T1; 20% and 18%, respectively, for T4 (segmentations provided); and 10% and 5%, respectively, for T5 (segmentation and time-integrated activity images provided). Conclusion: Variability in ADs was reduced as segmentation and time-integration data were provided to participants. Our results suggest that SPECT/CT-based imaging protocols generate more consistent and less variable results than planar imaging methods. Effort at standardizing segmentation and fitting should be made, as this may substantially reduce variability in ADs.
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DOI：
10.1007/s00259-010-1549-3
发表时间：
2011-01-01
影响因子：
9.1
作者：
Lassmann, M.;Chiesa, C.;Bardies, M.
通讯作者：
Bardies, M.
DOI：
10.2967/jnumed.111.100123
发表时间：
2012-08
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Dewaraja YK;Frey EC;Sgouros G;Brill AB;Roberson P;Zanzonico PB;Ljungberg M
通讯作者：
Ljungberg M
影响因子：
9.3
作者：
Dewaraja, Yuni K.;Mirando, David M.;Nelson, Aaron S.
通讯作者：
Nelson, Aaron S.
影响因子：
4
作者：
Brosch-Lenz J;Uribe C;Gosewisch A;Kaiser L;Todica A;Ilhan H;Gildehaus FJ;Bartenstein P;Rahmim A;Celler A;Ziegler S;Böning G
通讯作者：
Böning G
影响因子：
3.1
作者：
Fiedler, L.;Kellner, M.;Gildehaus, F. J.
通讯作者：
Gildehaus, F. J.