Involvement of Striatal Direct Pathway in Visual Spatial Attention in Mice.
Involvement of Striatal Direct Pathway in Visual Spatial Attention in Mice.
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DOI：
10.1016/j.cub.2020.08.083
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发表时间：
2020-12-07
期刊：
影响因子：
--
通讯作者：
Krauzlis RJ
中科院分区：
文献类型：
--
作者：
Wang L;Krauzlis RJ
除了众所周知的运动调节作用外，基底神经节还涉及一系列知觉功能。对这些不同角色的一个统一解释是，基底节根据行为背景控制着对特定运动或认知结果的承诺水平。如果这一解释适用于视觉空间注意力的分配，那么基底节回路的参与应该包括受试者对即将发生的事件的空间位置的预期，以及引导反应的视觉信号的路径选择。从信号检测理论的观点来看，承诺水平的这些变化可能对应于受试者决策标准的变化，这是最近被归因于视觉选择性注意的两个不同组成部分之一。在一项视觉空间注意任务中，我们使用小鼠背侧纹状体神经元的单侧光遗传激活来测试这一想法，利用与促进反应相关的“直接”通路中特定靶向中等刺神经元的能力。通过比较不同注意任务条件下的结果，我们发现，直接通路的激活导致了由视觉事件的空间概率和位置决定的绩效的变化。此外，在具有相同视觉刺激的条件下，当注意力被引导到对侧视野时，激活选择性地改变了决定标准。这些结果表明，在完成视觉空间注意的多种机制中，通过基底节的活动可能起着重要而独特的作用。通过将纹状体直接通路的光遗传操作与灵长类动物工作中适应的视觉注意任务相结合，Wang和Krauzlis表明，小鼠通过基底节的活动在视觉空间注意的分配中发挥着明显的作用。
The basal ganglia are implicated in a range of perceptual functions, in addition to their well-known role in the regulation of movement. One unifying explanation for these diverse roles is that the basal ganglia control the level of commitment to particular motor or cognitive outcomes based on the behavioral context. If this explanation is applicable to the allocation of visual spatial attention, then the involvement of basal ganglia circuits should incorporate the subject’s expectations about the spatial location of upcoming events as well as the routing of visual signals that guide the response. From the viewpoint of signal detection theory, these changes in the level of commitment might correspond to shifts in the subject’s decision criterion, one of two distinct components recently ascribed to visual selective attention. We tested this idea using unilateral optogenetic activation of neurons in the dorsal striatum of mice during a visual spatial attention task, taking advantage of the ability to specifically target medium spiny neurons in the “direct” pathway associated with promoting responses. By comparing results across attention task conditions, we found that direct-pathway activation caused changes in performance determined by the spatial probability and location of the visual event. Moreover, across conditions with identical visual stimulation, activation shifted the decision criterion selectively when attention was directed to the contralateral visual field. These results demonstrate that activity through the basal ganglia may play an important and distinct role among the multifarious mechanisms that accomplish visual spatial attention. By combining optogenetic manipulation of the striatal direct pathway with visual attention tasks adapted from work in primates, Wang and Krauzlis show that activity through the basal ganglia in mice plays a distinct role in the allocation of visual spatial attention.
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