Neuroprotective Effects of Hydroxysafflor Yellow A Against Excitotoxic Neuronal Death Partially Through Down-Regulation of NR2B-Containing NMDA Receptors
Neuroprotective Effects of Hydroxysafflor Yellow A Against Excitotoxic Neuronal Death Partially Through Down-Regulation of NR2B-Containing NMDA Receptors
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羟基红花黄 A 对兴奋性神经元死亡的神经保护作用部分是通过下调含有 NR2B 的 NMDA 受体来实现的
DOI：
10.1007/s11064-010-0191-6
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
招明高
中科院分区：
文献类型：
--
作者：
招明高
羟基红花黄色素A（HSYA）是红花（Carthamus tinctorius L.）的一种成分，在体内和体外均具有神经保护作用。本研究的目的是探讨HSYA对谷氨酸神经毒性的药理特性。
Hydroxysafflor yellow A (HSYA) is a component of the flowerCarthamus tinctoriusL. that elicits neuroprotective effects in vivo and in vitro. The purpose of this study was to investigate pharmacological properties of HSYA on neurotoxicity of glutamate in primary cultured rat cortical neurons along with its possible mechanism of action. After challenge withN-methyl-d-aspartate (NMDA, 100 μM) for 30 min, loss of cell viability and excessive apoptotic cell death were observed in cultured cortical neurons. However, the excitotoxic neuronal death was attenuated markedly by HSYA treatment. Western blot analysis revealed that HSYA decreased expression of Bax and rescued the balance of pro-and anti-apoptotic proteins. In addition, HSYA significantly reversed up-regulation of NR2B-containing NMDA receptors by exposure to NMDA, while it did not affect the expression of NR2A-containing NMDA receptors. These finding suggest that HSYA protects cortical neurons, at least partially, from inhibiting the expression NR2B-containing NMDA receptors and by regulating Bcl-2 family.
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影响因子：
--
作者：
Evstratova, A A;Mironova, E V;Antonov, S M
通讯作者：
Antonov, S M
影响因子：
2.9
作者：
Chen, Xia;Liu, Jie;Ding, Fei
通讯作者：
Ding, Fei
DOI：
10.1073/pnas.0903546106
发表时间：
2009-06-16
影响因子：
11.1
作者：
Stanika, Ruslan I.;Pivovarova, Natalia B.;Andrews, S. Brian
通讯作者：
Andrews, S. Brian
影响因子：
5.3
作者：
Liu, Yitao;Wong, Tak Pan;Wang, Yu Tian
通讯作者：
Wang, Yu Tian
NR2B 受体的下调部分促进了龙胆苦苷对持续性炎性疼痛的镇痛作用
影响因子：
4.7
作者：
Chen, Lei;Liu, Jin-cheng;Zhao, Ming-Gao
通讯作者：
Zhao, Ming-Gao