NK-B cell cross talk induces CXCR5 expression on natural killer cells.
NK-B cell cross talk induces CXCR5 expression on natural killer cells.
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DOI：
10.1016/j.isci.2021.103109
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发表时间：
2021-10-22
期刊：
影响因子：
5.8
通讯作者：
Müller-Trutwin M
中科院分区：
文献类型：
--
作者：
Rascle P;Jacquelin B;Petitdemange C;Contreras V;Planchais C;Lazzerini M;Dereuddre-Bosquet N;Le Grand R;Mouquet H;Huot N;Müller-Trutwin M
淋巴结内的B细胞滤泡一般不受CD8+T细胞和NK细胞的影响。非洲绿猴是猴免疫缺陷病毒(SIV)的自然宿主，在BCF中表现出NK细胞介导的病毒控制。SIVagm慢性感染AGM患者NK细胞向外周血中的迁移与CXCR5+NK细胞有关。我们的目的是确定导致NK细胞表达CXCR5的机制。我们发现在SIVagm感染后，LN中的CXCR5+NK细胞被诱导。随着B细胞的增殖，CXCR5+NK细胞优先聚集在BCF中。自体NK-B细胞在Transwell小室中共培养诱导CXCR5+NK细胞。转录组分析显示CXCR5+NK细胞表达Bcl6和IL6R。IL-6可诱导AGM和人NK细胞产生CXCR5。在SIVagm感染过程中，LN中IL6的表达水平高于SIVmac感染，且多由浆细胞产生。我们的研究揭示了一种B细胞依赖的NK细胞调节机制。IL-6可诱导CXCR5对NK细胞的作用CXCR5+NK细胞表达高水平的Bcl6和IL6R在SIVagm的淋巴结中IL-6+浆母细胞/浆细胞多于SIVmac感染的B细胞参与调节NK细胞向BCF的迁移
B cell follicles (BCFs) in lymph nodes (LNs) are generally exempt of CD8+ T and NK cells. African green monkeys (AGMs), a natural host of simian immunodeficiency virus (SIV), display NK cell-mediated viral control in BCF. NK cell migration into BCF in chronically SIVagm-infected AGM is associated with CXCR5+ NK cells. We aimed to identify the mechanism leading to CXCR5 expression on NK cells. We show that CXCR5+ NK cells in LN were induced following SIVagm infection. CXCR5+ NK cells accumulated preferentially in BCF with proliferating B cells. Autologous NK-B cell co-cultures in transwell chambers induced CXCR5+ NK cells. Transcriptome analysis of CXCR5+ NK cells revealed expression of bcl6 and IL6R. IL-6 induced CXCR5 on AGM and human NK cells. IL6 mRNA was detected in LN at higher levels during SIVagm than SIVmac infection and often produced by plasma cells. Our study reveals a mechanism of B cell-dependent NK cell regulation. IL-6 can induce CXCR5 on NK cells CXCR5+ NK cells expressed high levels of bcl6 and IL6R More IL-6+ plasmablast/plasma cells in lymph nodes in SIVagm than SIVmac infection B cells participate in the regulation of NK cell migration into BCF Immunology; Virology
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影响因子：
8.7
作者：
Estes JD
通讯作者：
Estes JD
影响因子：
20.3
作者：
Brenchley, Jason M.;Vinton, Carol;Estes, Jacob D.
通讯作者：
Estes, Jacob D.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
100.3
作者：
Davenport, Miles P.;Khoury, David S.;Kent, Stephen J.
通讯作者：
Kent, Stephen J.
影响因子：
5.5
作者：
Cook, Kevin D.;Kline, Hannah C.;Whitmire, Jason K.
通讯作者：
Whitmire, Jason K.