Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues.
Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues.
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DOI：
10.1111/imr.12070
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发表时间：
2013-07
影响因子：
8.7
通讯作者：
Estes JD
中科院分区：
文献类型：
--
作者：
Estes JD
获得性免疫缺陷综合征（AIDS）主要是一种淋巴组织疾病，因为人类免疫缺陷病毒（HIV）的主要靶细胞是CD4+ T淋巴细胞，主要存在于免疫系统的器官中。人类免疫缺陷病毒（HIV）感染对继发性淋巴组织，特别是淋巴结的影响至关重要，因为这些免疫器官是启动和促进免疫反应的主要部位，对淋巴细胞稳态的维持和生存至关重要。淋巴组织的基本结构要素，纤维母细胞网状细胞（FRC）网络，不仅构成了这些器官的结构框架，而且在t细胞生存所需的细胞因子的产生和储存中起着不可或缺的作用。FRC基质网络和CD4+ T淋巴细胞之间存在相互依赖的关系，以维持其生存和维持，这种关系在HIV疾病期间逐渐被破坏。HIV感染导致淋巴组织深刻的病理改变，由持续的慢性免疫激活和炎症引起，导致进行性胶原沉积和纤维化，破坏和破坏重要的FRC网络。在这篇综述中，我结合我们从hiv感染者身上学到的知识以及从非人灵长类动物免疫缺陷病毒感染模型中获得的宝贵知识，重点介绍了重要的继发性淋巴组织病理损伤的过程、机制和意义。
Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues, due to the fact that the main target cell of human immunodeficiency virus (HIV) is the CD4+ T lymphocyte that primarily resides within organs of the immune system. The impact of human immunodeficiency virus (HIV) infection on secondary lymphoid tissues, in particular lymph nodes, is critical to delineate, as these immune organs are the principal sites for initiating and facilitating immune responses and are critical for lymphocyte homeostatic maintenance and survival. The underlying structural elements of lymphoid tissues, fibroblastic reticular cell (FRC) network, not only form the architectural framework for these organs, but also play in integral role in the production and storage of cytokines needed for T-cell survival. There is an interdependent relationship between the FRC stromal network and CD4+ T lymphocytes for their survival and maintenance that is progressively disrupted during HIV disease. HIV infection results in profound pathological changes to lymphoid tissues induced by persistent chronic immune activation and inflammation that leads to progressive collagen deposition and fibrosis disrupting and damaging the important FRC network. In this review, I focus on the process, mechanisms, and the implications of pathological damage to important secondary lymphoid tissues, combining what we have learned from HIV-infected individuals as well as the invaluable knowledge gained from studies in non-human primate simian immunodeficiency virus infection models.
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作者：
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