Quantum dots as a platform for nanoparticle drug delivery vehicle design.
Quantum dots as a platform for nanoparticle drug delivery vehicle design.
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DOI：
10.1016/j.addr.2012.09.036
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发表时间：
2013-05
影响因子：
16.1
通讯作者：
Gao, Xiaohu
中科院分区：
文献类型：
--
作者：
Probst, Christine E.;Zrazhevskiy, Pavel;Bagalkot, Vaishali;Gao, Xiaohu
关键词：
基于纳米颗粒的药物递送（NDD）已经成为一种很有前途的方法，可以改善现有药物的疗效并使开发新疗法成为可能。概念验证研究表明，NDD系统具有同时降低药物毒性、提高生物利用度、增加循环时间、控制药物释放和靶向性的潜力。然而，以治疗特别具有挑战性的疾病（如癌症）为目标的NDD载体的临床转化将需要彻底了解纳米颗粒特性如何影响其在生物系统中的命运，特别是在体内。因此，一个高灵敏度、高分辨率、低成本的NDD各阶段系统评估模型系统是非常需要的。理论上，该系统应保持原有NDD载体的特性和行为，同时提供监测细胞内和全身纳米载体分布、降解、药物释放和清除的机制。对于这样的模型系统，量子点（QDots）提供了巨大的潜力。QDots具有小尺寸和多用途的表面化学特性，允许它们与几乎任何NDD载体结合，对整体特性的影响最小，并提供极好的光学特性，用于实时监测NDD载体在细胞和系统水平上的运输和药物释放。尽管由于QDots潜在的长期毒性，直接使用QDot进行药物递送仍然存在疑问，但由于QDot核心具有相似的尺寸和表面特性，因此可以很容易地用其他有机药物载体或更具生物相容性的无机造影剂（如金纳米粒子和磁性纳米粒子）代替QDot核心，从而促进将表征良好的NDD载体转化为临床，保持NDD成像能力。并可能提供额外的治疗功能，如光热疗法和磁转染。在这篇综述中，我们概述了使QDots成为纳米载体设计理想平台的独特特征，并讨论了如何将该模型应用于研究不同药物递送应用的NDD载体行为。
Nanoparticle-based drug delivery (NDD) has emerged as a promising approach to improving upon the efficacy of existing drugs and enabling the development of new therapies. Proof-of-concept studies have demonstrated the potential for NDD systems to simultaneously achieve reduced drug toxicity, improved bio-availability, increased circulation times, controlled drug release, and targeting. However, clinical translation of NDD vehicles with the goal of treating particularly challenging diseases, such as cancer, will require a thorough understanding of how nanoparticle properties influence their fate in biological systems, especially in vivo. Consequently, a model system for systematic evaluation of all stages of NDD with high sensitivity, high resolution, and low cost is highly desirable. In theory, this system should maintain the properties and behavior of the original NDD vehicle, while providing mechanisms for monitoring intracellular and systemic nanocarrier distribution, degradation, drug release, and clearance. For such a model system, quantum dots (QDots) offer great potential. QDots feature small size and versatile surface chemistry, allowing their incorporation within virtually any NDD vehicle with minimal effect on overall characteristics, and offer superb optical properties for real-time monitoring of NDD vehicle transport and drug release at both cellular and systemic levels. Though the direct use of QDots for drug delivery remains questionable due to their potential long-term toxicity, the QDot core can be easily replaced with other organic drug carriers or more biocompatible inorganic contrast agents (such as gold and magnetic nanoparticles) by their similar size and surface properties, facilitating translation of well characterized NDD vehicles to the clinic, maintaining NDD imaging capabilities, and potentially providing additional therapeutic functionalities such as photothermal therapy and magneto-transfection. In this review we outline unique features that make QDots an ideal platform for nanocarrier design and discuss how this model has been applied to study NDD vehicle behavior for diverse drug delivery applications.
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影响因子：
8
作者：
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通讯作者：
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影响因子：
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DOI：
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影响因子：
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