Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).
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腺苷受体拮抗剂黄嘌呤胺同源物 (XAC) 具有强效惊厥作用。
DOI：
10.1016/0024-3205(89)90091-x
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发表时间：
1989
期刊：
影响因子：
6.1
通讯作者：
Daly,JW
中科院分区：
文献类型：
--
作者：
Morgan,PF;Deckert,J;Jacobson,KA;Marangos,PJ;Daly,JW
The convulsant properties of xanthine amine congener (XAC, 8-(4-(2-aminoethyl)-aminocarbonxymethyloxy) are compared to those of caffeine. Male Swiss albino mice were infused with convulsants through a lateral tail vein. Convulsion thresholds (i.e. the amount of convulsants required to elicit convulsions) of 39.8±2.0 mg/kg (n=10) and 109.8±2.3 mg/kg (n=10) were calculated for XAC and caffeine respectively. Pretreatment of animals with the adenosine receptor agonists 2-chloradenosine, N6-cyclohexyladenosine or 5′-N-ethylcarboxamido-adenosine (1 mg/kg, i.p., 20 minutes prior to infusion) significantly decreased the seizure threshold of both XAC and caffeine. The adenosine uptake blockers, 6-nitrobenzylthioinosine o or dipyridamole (0.25 mg/kg, i.p., 20 minutes prior to infusion) did not significantly affect the seizure threshold to either XAC or caffeine. The benzodiazepam (5 mg/kg, i.p., 20 minutes prior to infusion) significantly increased the seizure threshold to both XAC (p < 0.05) and caffeine (p < 0.01), wherwas the benzodiazepine antagonist Ro 15–1788 (10 mg/kg, i.p., 20 minutes prior to infusion) significantly increased the seizure threshold to caffeine (p < 0.01), but not XAC. The results suggest that actions at benzodiazepine receptors may be a tenable hypothesis to explain the convulsant actions of caffeine, but not those of XAC.
来自人肝脏的两种醛脱氢酶。
DOI：
--
发表时间：
1977
期刊：
Biochimica et Biophysica Acta
影响因子：
--
作者：
Norma J. Greenfield;R. Pietruszko
通讯作者：
R. Pietruszko
酒精代谢酶：人体活检和培养成纤维细胞中同工酶的研究
影响因子：
3.5
作者：
H. Goedde;D. Agarwal;S. Harada
通讯作者：
S. Harada
DOI：
10.1073/pnas.82.11.3771
发表时间：
1985-01-01
影响因子：
11.1
作者：
HSU, LC;TANI, K;YOSHIDA, A
通讯作者：
YOSHIDA, A