Biologics for the Treatment of Allergic Rhinitis, Chronic Rhinosinusitis, and Nasal Polyposis.
Biologics for the Treatment of Allergic Rhinitis, Chronic Rhinosinusitis, and Nasal Polyposis.
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DOI：
10.1016/j.iac.2020.06.001
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发表时间：
2020-11
影响因子：
2.6
通讯作者：
Borish L
中科院分区：
文献类型：
--
作者：
Eschenbacher W;Straesser M;Knoeddler A;Li RC;Borish L
变应性鼻炎(AR)，慢性鼻窦炎(CRS)的许多表现，以及CRS合并鼻息肉(NP)的大多数表现被认为是2型(T2)炎症性疾病。这些T2高炎症状态的特点是嗜酸性粒细胞、嗜碱性粒细胞、肥大细胞和其他炎症细胞的渗透，并被与Th2效应细胞相关的细胞因子的强烈表达所识别，特别是白细胞介素IL-4、IL-5和IL-13。T2High一词现在是这种炎症表型的首选术语，因为它认识到Th2效应细胞因子的许多额外来源，如固有淋巴2细胞(ILC2s)、嗜酸性粒细胞、肥大细胞和许多其他细胞。尽管这些T2细胞因子不是专门针对上呼吸道的T2疾病开发的，但对这些疾病的存在和严重程度的认识导致了针对其他T2疾病(特应性皮炎(AD)和哮喘)开发的生物制剂作为治疗选择的探索。本章将回顾生物制剂作为变应性鼻炎、慢性鼻窦炎和鼻息肉的潜在干预措施的使用。
Allergic rhinitis (AR), many presentations of chronic rhinosinusitis (CRS), and most presentations of CRS with nasal polyposis (NP) are recognized as type 2 (T2) inflammatory diseases. These T2high inflammatory conditions are characterized by infiltration with eosinophils, basophils, mast cells, and other inflammatory cells and are recognized by the robust expression of cytokines associated with Th2 effector cells, specifically the interleukins (IL) IL-4, IL-5, and IL-13. The term T2high is now the preferred term for this inflammatory phenotype, in recognition of the numerous additional sources of Th2 effector cytokines such as innate lymphoid 2 cells (ILC2s), eosinophils, mast cells, and numerous others. Although not specifically developed for T2 diseases of the upper airway, recognition of the roles of these T2 cytokines in driving the presence and severity of these conditions has led to the exploration of biologics that were developed for other T2 conditions (atopic dermatitis (AD) and asthma) as therapeutic options. This chapter will review the use of biologics as potential interventions in allergic rhinitis, chronic rhinosinusitis, and nasal polyposis.
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影响因子：
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