Presence of Acute Phase Changes in Zinc, Iron, and Copper Metabolism in Turkey Embryos
Presence of Acute Phase Changes in Zinc, Iron, and Copper Metabolism in Turkey Embryos
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火鸡胚胎中锌、铁和铜代谢的急性相变的存在
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
D. Laurin
中科院分区：
文献类型：
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作者：
K. Klasing;M. Richards;S. Darcey;D. Laurin
研究了火鸡胚胎中微量矿物质代谢的急性时相变化。注射内毒素后，无论是卵内还是体外孵化的胚胎，血清铜和肝脏锌浓度均升高，血清锌浓度降低。当内毒素肌肉注射到羊水中，或者注射到绒毛尿囊膜上时，锌和铜的代谢发生了变化。与禽类不同的是，胚胎不会通过降低血清铁浓度来应对炎症挑战。胚胎血清锌和铜以及肝脏锌浓度的急性期变化与雏鸡相似。肝脏锌浓度的升高与金属硫蛋白(MT)中的锌含量增加有关。将白介素1粗品注入胚胎，可引起肝脏锌和MT浓度升高，与内毒素注射相似，提示该细胞因子在调节胚胎锌代谢的急性时相变化中起作用。
Acute phase changes in trace mineral metabolism were examined in turkey embryos. An endotoxin injection resulted in increased concentrations of serum copper and liver zinc and decreased concentrations of serum zinc in embryos incubated either in ovo or ex ovo. Changes in zinc and copper metabolism occurred when endotoxin either was injected intramuscularly, into the amnionic fluid, or administered onto the chorioallantoic membrane. Unlike poults, embryos did not respond to an inflammatory challenge with decreased serum iron concentrations. Acute phase changes in embryo serum zinc and copper as well as liver zinc concentrations were similar to those in poults. Increased liver zinc concentrations were associated with increased zinc in metallothionein (MT). An injection of a crude interleukin 1 preparation into embryos resulted in similar increases in hepatic zinc and MT concentrations as an endotoxin injection, suggesting a role for this cytokine in mediating the acute phase changes in embryonic zinc metabolism.
新生儿吞噬细胞产生白细胞热原。
DOI：
10.1093/infdis/144.4.337
发表时间：
1981
期刊：
The Journal of infectious diseases
影响因子：
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作者：
Dinarello,CA;Shparber,M;KentJr,EF;Wolff,SM
通讯作者：
Wolff,SM